Art

J-GLOBAL ID：201902262840753303   Reference number：19A1456613

Encapsulation of tissue plasminogen activator in pH-sensitive self-assembled antioxidant nanoparticles for ischemic stroke treatment - Synergistic effect of thrombolysis and antioxidant -

虚血性脳卒中治療のためのpH感受性自己集合抗酸化ナノ粒子における組織プラスミノーゲン活性化因子のカプセル化-血栓溶解と抗酸化剤の相乗効果【JST・京大機械翻訳】

Author (11)： Mei Ting (Department of Materials Science, Graduate School of Pure and Applied Science, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, 305-8573, Japan) ,  Kim Ahram (Department of Materials Science, Graduate School of Pure and Applied Science, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, 305-8573, Japan) ,  Vong Long Binh (Department of Materials Science, Graduate School of Pure and Applied Science, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, 305-8573, Japan) ,  Vong Long Binh (Department of Biomedical Engineering, International University, Vietnam National University Ho Chi Minh City (VNU-HCM), Ho Chi Minh, 703000, Viet Nam) ,  Marushima Aiki (Department of Neurosurgery, Graduate School of Comprehensive Human Science, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, 305-8573, Japan) ,  Puentes Sandra (Department of Intelligent Interaction Technologies, Faculty of Engineering, Information and Systems, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, 305-8573, Japan) ,  Matsumaru Yuji (Department of Neurosurgery, Graduate School of Comprehensive Human Science, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, 305-8573, Japan) ,  Matsumura Akira (Department of Neurosurgery, Graduate School of Comprehensive Human Science, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, 305-8573, Japan) ,  Nagasaki Yukio (Department of Materials Science, Graduate School of Pure and Applied Science, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, 305-8573, Japan) ,  Nagasaki Yukio (Master’s School in Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, 305-8573, Japan) ,  Nagasaki Yukio (Center for Research in Isotopes and Environmental Dynamics (CRiED), University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, 305-8573, Japan)
Material： Biomaterials
Volume： 215  Page： Null  Publication year： 2019 
JST Material Number： C0964B  ISSN： 0142-9612  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： The medical treatment for stro...

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Thesaurus term： oxidation-reduction reaction ,  nitroxide ,  bioavailability ,  *self assembly ,  Half-Life ,  *ischemia ,  *nano particle ,  Reperfusion ,  *antioxidation ,  oxidative stress ,  *Thrombosis ,  antioxidant ,  *cerebral apoplexy ,  *encapsulation ,  polyion complex ,  *Thromboembolism

Author keywords (6)： Ischemia-reperfusion treatment ,  Tissue plasminogen activator (t-PA) ,  Reactive oxygen species (ROS) ,  Redox nanoparticles ,  Ischemic stroke ,  Hemorrhagic transformation

JST classification (1)： Medical materials  (GA05040H)

Terms in the title (11)： 虚血性脳卒中 ,  治療 ,  pH感受性 ,  自己集合 ,  酸化 ,  ナノ粒子 ,  組織プラスミノーゲン活性化因子 ,  カプセル化 ,  血栓溶解 ,  抗酸化剤 ,  相乗効果