Art

J-GLOBAL ID：201902263410976573   Reference number：19A2482099

Analgesic Effects of Ephedra Herb Extract, Ephedrine Alkaloids-Free Ephedra Herb Extract, Ephedrine, and Pseudoephedrine on Formalin-Induced Pain

ホルマリン誘発疼痛に対するEphedraハーブ抽出物,エフェドリンアルカロイド非含有Ephedraハーブ抽出物,エフェドリン,およびプソイドエフェドリンの鎮痛効果

Author (19)： Nakamori Shunsuke (Department of Pharmacognosy, School of Pharmacy, Kitasato University) ,  Nakamori Shunsuke (Oriental Medicine Research Center of Kitasato University) ,  Takahashi Jun (Department of Pharmacognosy, School of Pharmacy, Kitasato University) ,  Takahashi Jun (Oriental Medicine Research Center of Kitasato University) ,  Hyuga Sumiko (Oriental Medicine Research Center of Kitasato University) ,  Yang Jinwei (Tokiwa Phytochemical Co., Ltd.) ,  Takemoto Hiroaki (Department of Pharmacognosy, School of Pharmacy, Kitasato University) ,  Takemoto Hiroaki (Oriental Medicine Research Center of Kitasato University) ,  Maruyama Takuro (National Institute of Health Sciences) ,  Oshima Naohiro (Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  Uchiyama Nahoko (National Institute of Health Sciences) ,  Amakura Yoshiaki (Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University) ,  Hyuga Masashi (National Institute of Health Sciences) ,  Hakamatsuka Takashi (National Institute of Health Sciences) ,  Goda Yukihiro (National Institute of Health Sciences) ,  Odaguchi Hiroshi (Oriental Medicine Research Center of Kitasato University) ,  Hanawa Toshihiko (Oriental Medicine Research Center of Kitasato University) ,  Kobayashi Yoshinori (Department of Pharmacognosy, School of Pharmacy, Kitasato University) ,  Kobayashi Yoshinori (Oriental Medicine Research Center of Kitasato University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 42  Issue： 9  Page： 1538-1544(J-STAGE)  Publication year： 2019 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： mouse(animal) ,...
Semi thesaurus term： formalin test ,...

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Author keywords (10)： Ephedra Herb ,  ephedrine ,  analgesic effect ,  formalin test ,  pain ,  Ephedra Herb ,  ephedrine ,  analgesic effect ,  formalin test ,  pain

JST classification (2)： Basic research of pharmacology of crude drugs  (GX06020J) ,  Basic research of antipyretic analgesics  (GW03040H)

Substance index (2)： Ephedrine ,  Pseudoephedrine

Reference (34)：

• 1) The Ministry of Health, Labor, and Welfare of Japan. The Japanese Pharmacopoeia. 17th edition, Tokyo, Japan (2016).
• 2) Hikino H, Konno C, Takata H, Tamada M. Antiinflammatory principle of ephedra herbs. Chem. Pharm. Bull., 28, 2900-2904 (1980).
• 3) Hyuga S, Hyuga M, Oshima N, Maruyama T, Kamakura H, Yamashita T, Yoshimura M, Amakura Y, Hakamatsuka T, Odaguchi H, Goda Y, Hanawa T. Ephedrine alkaloids-free Ephedra Herb extract: a safer alternative to ephedra with comparable analgesic, anticancer, and anti-influenza activities. J. Nat. Med., 70, 571-583 (2016).
• 4) Mantani N, Andoh T, Kawamata H, Terasawa K, Ochiai H. Inhibitory effect of Ephedrae herba, an oriental traditional medicine, on the growth of influenza A/PR/8 virus in MDCK cells. Antiviral Res., 44, 193-200 (1999).
• 5) Hyuga S, Shiraishi M, Hyuga M, Goda Y, Hanawa T. Ephedrae herba, a major component of maoto, inhibits the HGF-induced motility of human breast cancer MDA-MB-231 cells through suppression of c-Met tyrosine phosphorylation and c-Met expression. J. Trad. Med, 28, 128-138 (2011).

Terms in the title (10)： ホルマリン ,  誘発 ,  疼痛 ,  Ephedra ,  ハーブ ,  抽出物 ,  エフェドリン ,  アルカロイド ,  プソイドエフェドリン ,  鎮痛効果