Art

J-GLOBAL ID：201902264445293753   Reference number：19A0632984

Human Pluripotent Stem Cell-Derived Tumor Model Uncovers the Embryonic Stem Cell Signature as a Key Driver in Atypical Teratoid/Rhabdoid Tumor

ヒト多能性幹細胞由来腫瘍モデルは,非定型奇形腫/ラブドイド腫瘍における重要なドライバーとして胚幹細胞シグネチャーを明らかにする【JST・京大機械翻訳】

Author (22)： Terada Yukinori (Division of Stem Cell Pathology, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Terada Yukinori (Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan) ,  Terada Yukinori (Department of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan) ,  Jo Norihide (Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan) ,  Arakawa Yoshiki (Department of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan) ,  Sakakura Megumi (Division of Stem Cell Pathology, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Sakakura Megumi (Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan) ,  Yamada Yosuke (Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan) ,  Ukai Tomoyo (Division of Stem Cell Pathology, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Ukai Tomoyo (Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan) ,  Kabata Mio (Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan) ,  Mitsunaga Kanae (Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan) ,  Mineharu Yohei (Department of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan) ,  Ohta Sho (Division of Stem Cell Pathology, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Nakagawa Masato (Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan) ,  Miyamoto Susumu (Department of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan) ,  Yamamoto Takuya (Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan) ,  Yamamoto Takuya (AMED-CREST, AMED 1-7-1 Otemachi, Chiyoda-ku, Tokyo 100-0004, Japan) ,  Yamamoto Takuya (Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Yamada Yasuhiro (Division of Stem Cell Pathology, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Yamada Yasuhiro (Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan) ,  Yamada Yasuhiro (AMED-CREST, AMED 1-7-1 Otemachi, Chiyoda-ku, Tokyo 100-0004, Japan)
Material： Cell Reports
Volume： 26  Issue： 10  Page： 2608-2621.e6  Publication year： 2019 
JST Material Number： W3124A  ISSN： 2211-1247  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Atypical teratoid/rhabdoid tum...

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Thesaurus term： prognosis ,  *human(primates) ,  mouse(animal) ,  gene expression ,  *char ,  *ES cell ,  brain tumor ,  *tumor ,  variation(biology) ,  *versatility ,  *teratoma
Semi thesaurus term： 候補遺伝子 ,  DNAメチル化 ,  予後不良 ,  *ラブドイド腫瘍 , 【Automatic Indexing@JST】

Author keywords (8)： atypical teratoid/rhabdoid tumor ,  pediatric tumor ,  embryonic stem cell ,  induced pluripotent stem cell ,  ESC-like signature ,  pluripotency ,  dedifferentiation ,  SMARCB1

JST classification (1)： Cell physiology in general  (EF02010S)

Terms in the title (10)： ヒト ,  多能性幹細胞 ,  腫瘍 ,  モデル ,  定型 ,  奇形腫 ,  ラブドイド腫瘍 ,  ドライバー ,  胚幹細胞 ,  シグネチャー