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J-GLOBAL ID：201902264521562880   Reference number：19A1650216

Metabolic Engineering of Bacillus subtilis Toward Taxadiene Biosynthesis as the First Committed Step for Taxol Production

タキソール生産のための最初の関与段階としてのタキサジエン生合成に向けた枯草菌の代謝工学【JST・京大機械翻訳】

Author (6)： Abdallah Ingy I. (1Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, Netherlands) ,  Pramastya Hegar (1Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, Netherlands) ,  Pramastya Hegar (2Pharmaceutical Biology Research Group, School of Pharmacy, Institut Teknologi Bandung, Bandung, Indonesia) ,  van Merkerk Ronald (1Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, Netherlands) ,  Sukrasno (2Pharmaceutical Biology Research Group, School of Pharmacy, Institut Teknologi Bandung, Bandung, Indonesia) ,  Quax Wim J. (1Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, Netherlands)
Material： Frontiers in Microbiology (Web)
Volume： 10  Page： 218  Publication year： 2019 
JST Material Number： U7080A  ISSN： 1664-302X  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Terpenoids are natural product...

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Thesaurus term： terpenoid ,  *biosynthesis ,  phosphate ,  natural material ,  *metabolism ,  *Bacillus subtilis ,  synthase ,  vector(genetics) ,  precursor(substance) ,  enzyme ,  alicyclic compound ,  lactone ,  bridged compound
Semi thesaurus term： 半合成 ,  過剰発現 ,  生合成経路 ,  *代謝工学 , 【Automatic Indexing@JST】

Author keywords (6)： Bacillus subtilis ,  metabolite ,  MEP ,  GGPPS ,  taxadiene ,  Taxol

JST classification (2)： Microbial metabolite production  (FK03020A) ,  Metabolism and nutrition  (EG03054K)

Substance index (1)： Artemisinin

Reference (53)：

• Abdallah I. I., Quax W. J. (2017). A glimpse into the biosynthesis of terpenoids. KnE Life Sci. 81-98. doi: doi: 10.18502/kls.v3i5.981
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• Baloglu E., Kingston D. G. I. (1999). A new semisynthesis of paclitaxel from baccatin III. J. Nat. Prod. 62, 1068-1071. doi: doi: 10.1021/np990040k
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• Barkovich R., Liao J. C. (2001). REVIEW: metabolic engineering of isoprenoids. Metab. Eng. 3, 27-39. doi: doi: 10.1006/mben.2000.0168

Terms in the title (5)： タキソール ,  段階 ,  生合成 ,  枯草菌 ,  代謝工学