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J-GLOBAL ID：201902265186061252   Reference number：19A1462404

Ectopic expression of DNA methyltransferases DNMT3A2 and DNMT3L leads to aberrant hypermethylation and postnatal lethality in mice

DNAメチルトランスフェラーゼDNMT3A2とDNMT3Lの異所性発現はマウスにおける異常な高メチル化と出生後致死性をもたらす【JST・京大機械翻訳】

Author (9)： Sasaki Keisuke (Department of Bioscience, Tokyo University of Agriculture, Tokyo, Japan) ,  Sasaki Keisuke (Research Fellow of Japan Society for the Promotion of Science, Tokyo, Japan) ,  Hara Satoshi (Department of Bioscience, Tokyo University of Agriculture, Tokyo, Japan) ,  Yamakami Reina (Department of Bioscience, Tokyo University of Agriculture, Tokyo, Japan) ,  Sato Yusuke (Department of Bioscience, Tokyo University of Agriculture, Tokyo, Japan) ,  Hasegawa Saki (Department of Bioscience, Tokyo University of Agriculture, Tokyo, Japan) ,  Kono Tomohiro (Department of Bioscience, Tokyo University of Agriculture, Tokyo, Japan) ,  Morohaku Kanako (Department of Bioscience, Tokyo University of Agriculture, Tokyo, Japan) ,  Obata Yayoi (Department of Bioscience, Tokyo University of Agriculture, Tokyo, Japan)
Material： Molecular Reproduction and Development  (Molecular Reproduction & Development)
Volume： 86  Issue： 6  Page： 614-623  Publication year： 2019 
JST Material Number： T0932A  ISSN： 1040-452X  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： DNA methylation is generally k...

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Thesaurus term： *Mus musculus ,  gene expression ,  *DNA methyltransferase ,  Down-Regulation ,  gene ,  perinatal period ,  reproductive cell ,  allele ,  inactivation ,  transgenic mouse ,  Heart ,  *Methylation ,  somatic cell ,  DNA Methylation ,  *Live Birth ,  *Myomorpha ,  molecular genetic phenomenon

Author keywords (5)： DNA methylation ,  DNA methyltransferases ,  Down’s syndrome ,  genomic imprinting ,  ontogeny

JST classification (1)： Reproductive(=genital)organs  (EJ15020P)

Terms in the title (6)： DNAメチルトランスフェラーゼ ,  異所性発現 ,  マウス ,  メチル化 ,  出生 ,  致死性