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J-GLOBAL ID：201902265212513383   Reference number：19A1742653

Cannabidiol metabolism revisited: tentative identification of novel decarbonylated metabolites of cannabidiol formed by human liver microsomes and recombinant cytochrome P450 3A4

カンナビジオール代謝の再検討:ヒト肝ミクロソームと組換えチトクロームP450 3A4により形成されたカンナビジオールの新規脱カルボニル化代謝物の暫定的同定

Author (6)： Watanabe Kazuhito (Daiichi University of Pharmacy, Fukuoka, Japan) ,  Usami Noriyuki (Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan) ,  Osada Shigehiro (Daiichi University of Pharmacy, Fukuoka, Japan) ,  Narimatsu Shizuo (Faculty of Health and Nutrition, Minami Kyushu University, Miyazaki, Japan) ,  Yamamoto Ikuo (Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan) ,  Yoshimura Hidetoshi (Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan)
Material： Forensic Toxicology  (Forensic Toxicol)
Volume： 37  Issue： 2  Page： 449-455  Publication year： Jul. 2019 
JST Material Number： L0680A  ISSN： 1860-8965  Document type： Article
Article type： 短報  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *microsome ,...
Semi thesaurus term： gas chromatography-mass spectrometry ,...

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Author keywords (6)： Cannabidiol ,  Decarbonylation ,  Metabolism ,  Human liver microsomes ,  CYP3A4 ,  Cyclopentadienol

JST classification (3)： Animal biochemistry  (EJ01050P) ,  Aromatic monocyclic phenols and polyphenols  (CF05090V) ,  Analysis of drugs  (GV01040Q)

Substance index (5)： (4R)-4-Isopropenyl-3-(2-oxo-4-pentyl-3-cyclopentenyl)-1-methylcyclohexene ,  (4R)-4-Isopropenyl-3-(2-hydroxy-4-pentyl-1,3-cyclopentadienyl)-1-methylcyclohexene ,  (4R)-4-Isopropenyl-3-[2-(2,3,4,5,6-pentafluorobenzyloxyimino)-4-pentyl-3-cyclopentenyl]-1-methylcyclohexene ,  (4R)-4-Isopropenyl-3-[2-(trimethylsiloxy)-4-pentyl-1,3-cyclopentadienyl]-1-methylcyclohexene ,  Cannabidiol

Terms in the title (8)： カンナビジオール ,  代謝 ,  ヒト肝ミクロソーム ,  組換え ,  チトクロームP450 ,  脱カルボニル化 ,  代謝物 ,  同定