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J-GLOBAL ID：201902265892305616   Reference number：19A0881383

HIV Tat/P-TEFb Interaction: A Potential Target for Novel Anti-HIV Therapies

HIV TAP/p-TEFb相互作用:新規抗HIV療法のための潜在的標的【JST・京大機械翻訳】

Author (3)： Asamitsu Kaori (Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan) ,  Fujinaga Koh (Department of Medicine, Microbiology and Immunology, University of California, San Francisco, CA 94143-0703, USA) ,  Okamoto Takashi (Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan)
Material： Molecules (Web)
Volume： 23  Issue： 4  Page： 933  Publication year： 2018 
JST Material Number： U7014A  ISSN： 1420-3049  CODEN： MOLEFW  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Transcription is a crucial ste...

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Thesaurus term： life cycle ,  HIV1 ,  transcription factor ,  *HIV ,  *interaction ,  regulator ,  genome ,  literature review ,  therapeutic planning
Semi thesaurus term： 分子機構 ,  ウイルスDNA ,  宿主細胞 ,  転写活性化因子 ,  ウイルス潜伏 ,  *抗HIV療法 , 【Automatic Indexing@JST】

Author keywords (6)： HIV transcription ,  P-TEFb ,  cyclin T1 ,  CDK9 ,  Tat ,  HEXIM1

JST classification (2)： Basic research of pharmacology of crude drugs  (GX06020J) ,  Basic research of anti-inflammatory drugs  (GW15010T)

Reference (124)：

• Joint United Nations Programme on HIV/AIDS (UNAIDS). Global Report: UNAIDS Report on the Global AIDS Epidemic 2013. Available online: http://www.unaids.org/en/media/unaids/contentassets/documents/epidemiology/2013/gr2013/UNAIDS_Global_Report_2013_en.pdf (accessed on 1 March 2018).
• Deeks, S.G.; Autran, B.; Berkhout, B.; Benkirane, M.; Cairns, S.; Chomont, N.; Chun, T.W.; Churchill, M.; Di Mascio, M.; Katlama, C.; et al. Towards an HIV cure: A global scientific strategy. Nat. Rev. Immunol. 2012, 12, 607-614.
• Jones, K.A.; Kadonaga, J.T.; Luciw, P.A.; Tjian, R. Activation of the AIDS retrovirus promoter by the cellular transcription factor, Sp1. Science 1986, 232, 755-759.
• Shaw, J.P.; Utz, P.J.; Durand, D.B.; Toole, J.J.; Emmel, E.A.; Crabtree, G.R. Identification of a putative regulator of early T cell activation genes. Science 1988, 241, 202-205.
• Osborn, L.; Kunkel, S.; Nabel, G.J. Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B. Proc. Natl. Acad. Sci. USA 1989, 86, 2336-2340.

Terms in the title (6)： HIV ,  TAP ,  P-TEFb ,  相互作用 ,  抗HIV療法 ,  標的