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J-GLOBAL ID：201902266671522825   Reference number：19A1289582

Eosinophilic Upper Airway Inflammation in a Murine Model Using an Adoptive Transfer System Induces Hyposmia and Epithelial Layer Injury with Convex Lesions

養子移入システムを用いたマウスモデルにおける好酸球性上気道炎症は,凸病変を伴う低浸透圧および上皮層損傷を誘発する【JST・京大機械翻訳】

Author (20)： Kanda Akira (Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Hirakata 573-1010, Japan) ,  Kanda Akira (Allergy Center, Kansai Medical University, Hirakata 573-1010, Japan) ,  Kondo Kenji (Department of Otolaryngology and Head and Neck Surgery, Graduate School of Medicine, the University of Tokyo Hospital, Tokyo, 113-8655, Japan) ,  Hosaka Naoki (Department of Pathology, Fuchu Hospital, Izumi 594-0076, Japan) ,  Kobayashi Yoshiki (Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Hirakata 573-1010, Japan) ,  Kobayashi Yoshiki (Allergy Center, Kansai Medical University, Hirakata 573-1010, Japan) ,  Bui Dan Van (Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Hirakata 573-1010, Japan) ,  Yun Yasutaka (Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Hirakata 573-1010, Japan) ,  Suzuki Kensuke (Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Hirakata 573-1010, Japan) ,  Sawada Shunsuke (Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Hirakata 573-1010, Japan) ,  Asako Mikiya (Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Hirakata 573-1010, Japan) ,  Asako Mikiya (Allergy Center, Kansai Medical University, Hirakata 573-1010, Japan) ,  Nakamura Akihiko (Nakamura ENT Clinic, Sakai 591-8025, Japan) ,  Tomoda Koichi (Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Hirakata 573-1010, Japan) ,  Sakata Yoshiko (Central Research Laboratory, Kansai Medical University, Hirakata 573-1010, Japan) ,  Tsuta Koji (Department of Pathology, Kansai Medical University, Hirakata 573-1010, Japan) ,  Dombrowicz David (EGID, Inserm, CHU Lille, Institut Pasteur de Lille, U1011, University of Lille, 59019 Lille, France) ,  Kawauchi Hideyuki (Department of Otorhinolaryngology, Shimane University Faculty of Medicine, Izumo 693-0021, Japan) ,  Fujieda Shigeharu (Department of Otorhinolaryngology Head & Neck Surgery, University of Fukui, Fukui 910-1193, Japan) ,  Iwai Hiroshi (Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Hirakata 573-1010, Japan)
Material： Medical Sciences (Web)
Volume： 7  Issue： 2  Page： 22  Publication year： 2019 
JST Material Number： U7240A  ISSN： 2076-3271  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Background: Chronic rhinosinus...

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Thesaurus term： computed tomography ,  interleukin 5 ,  nasal cavity ,  antigen ,  transgenic mouse ,  pathological state ,  paranasal sinus ,  edema ,  allergic reaction ,  asthma ,  *epithelium ,  eosinophilia ,  Eumycetes ,  human(primates) ,  *eosinophils

Author keywords (5)： allergic rhinitis ,  chronic rhino sinusitis ,  nasal poly ,  eosinophil ,  hyposmia

JST classification (5)： Aromatic monocyclic phenols and polyphenols  (CF05090V) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Structure and chemistry of genes  (EC02020U) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Cardiovascular system diseases  (GJ03000C)

Reference (36)：

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• Blanchard, C.; Rothenberg, M.E. Biology of the eosinophil. Adv. Immunol. 2009, 101, 81-121.
• Rosenberg, H.F.; Dyer, K.D.; Foster, P.S. Eosinophils: Changing perspectives in health and disease. Nat. Rev. Immunol. 2013, 13, 9-22.
• Foley, S.C.; Prefontaine, D.; Hamid, Q. Images in allergy and immunology: Role of eosinophils in airway remodeling. J. Allergy Clin. Immunol. 2007, 119, 1563-1566.
• Schleimer, R.P. Immunopathogenesis of Chronic Rhinosinusitis and Nasal Polyposis. Annu. Rev. Pathol. 2017, 12, 331-357.

Terms in the title (10)： 養子移入 ,  マウスモデル ,  好酸球 ,  上気道炎症 ,  凸 ,  病変 ,  浸透圧 ,  皮層 ,  損傷 ,  誘発