Art

J-GLOBAL ID：201902266743182860   Reference number：19A1751392

A proposed simple screening method to determine relative contributions of CYP3A4 and CYP3A5 to drug metabolism in vitro

in vitroにおける薬物代謝へのCYP3A4及びCYP3A5の相対的寄与を明らかにする簡便なスクリーニング法の提案

Author (19)： Matsumoto Jun (Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan) ,  Nakamura Hiroyoshi (Department of Pharmaceutical Sciences, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi, 324-8501, Japan) ,  Nakamura Hiroyoshi (Division of Pharmacy, International University of Health and Welfare Mita Hospital, 1-4-3 Mita, Minato-ku, Tokyo, 108-8329, Japan) ,  Nakamura Hiroyoshi (Graduate School of Pharmaceutical Sciences, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi, 324-8501, Japan) ,  San Su Nwe (Graduate School of Pharmaceutical Sciences, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi, 324-8501, Japan) ,  Sato Hikari (Department of Pharmaceutical Sciences, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi, 324-8501, Japan) ,  Takezawa Manami (Department of Pharmaceutical Sciences, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi, 324-8501, Japan) ,  Kishi Ryuto (Department of Pharmaceutical Sciences, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi, 324-8501, Japan) ,  Kito Yutaro (Department of Pharmaceutical Sciences, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi, 324-8501, Japan) ,  Sugano Junko (Department of Pharmaceutical Sciences, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi, 324-8501, Japan) ,  Izuki Mai (Department of Pharmaceutical Sciences, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi, 324-8501, Japan) ,  Yanagisawa Nao (Department of Pharmaceutical Sciences, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi, 324-8501, Japan) ,  Ikeda Naoki (Department of Pharmaceutical Sciences, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi, 324-8501, Japan) ,  Saito Yusuke (Department of Pharmaceutical Sciences, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi, 324-8501, Japan) ,  Kato Yoshinori (Department of Pharmaceutical Sciences, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi, 324-8501, Japan) ,  Yamada Harumi (Department of Pharmaceutical Sciences, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi, 324-8501, Japan) ,  Yamada Harumi (Graduate School of Pharmaceutical Sciences, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi, 324-8501, Japan) ,  Fujiyoshi Masachika (Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan) ,  Ariyoshi Noritaka (Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan)
Material： Personalized Medicine Universe  (Personalized Med Universe)
Volume： 8  Page： 41-44  Publication year： Jul. 2019 
JST Material Number： W2403A  ISSN： 2186-4969  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： drug metabolism ,...
Semi thesaurus term： CYP3A4 ,...

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Author keywords (5)： CYP3A ,  CYP3A5*3 allele ,  P450 Glo Assay system ,  Pharmacokinetics ,  Pharmacogenetics

JST classification (1)： Basic biopharmacy  (GY01021U)

Terms in the title (5)： 薬物代謝 ,  CYP3A4 ,  CYP3A5 ,  スクリーニング法 ,  提案