Art

J-GLOBAL ID：201902267512425168   Reference number：19A0880985

Substrate Binding Switches the Conformation at the Lynchpin Site in the Substrate-Binding Domain of Human Hsp70 to Enable Allosteric Interdomain Communication

基質結合はアロステリックなドメイン間コミュニケーションを可能にするヒトHSP70の基質結合ドメインのLynchpin部位における立体配座をスイッチする【JST・京大機械翻訳】

Author (5)： Umehara Kohei (Department of Mathematical and Life Sciences, School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8526, Japan) ,  Hoshikawa Miho (Department of Mathematical and Life Sciences, School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8526, Japan) ,  Tochio Naoya (Research Center for the Mathematics on Chromatin Live Dynamics (RcMcD), Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8526, Japan) ,  Tate Shin-ichi (Department of Mathematical and Life Sciences, School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8526, Japan) ,  Tate Shin-ichi (Research Center for the Mathematics on Chromatin Live Dynamics (RcMcD), Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8526, Japan)
Material： Molecules (Web)
Volume： 23  Issue： 3  Page： 528  Publication year： 2018 
JST Material Number： U7014A  ISSN： 1420-3049  CODEN： MOLEFW  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： The stress-induced 70 kDa heat...

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Thesaurus term： *binding site ,  *human ,  Bacteria ,  *steric conformation ,  *substrate (biochemistry) ,  ATPase ,  *Communication ,  NMR ,  homeostasis ,  peptide bond ,  orthologue ,  alpha helix ,  C-terminal side ,  *domain structure ,  microorganism
Semi thesaurus term： 残基 , 【Automatic Indexing@JST】

Author keywords (4)： Hsp70 ,  SBD ,  αLid ,  NMR

JST classification (1)： Molecular structure  (EB03020Y)

Reference (50)：

• Mayer, M.P. Hsp70 chaperone dynamics and molecular mechanism. Trends Biochem. Sci. 2013, 38, 507-514.
• Mayer, M.P.; Bukau, B. Hsp70 chaperones: Cellular functions and molecular mechanism. Cell. Mol. Life Sci. 2005, 62, 670-684.
• Meimaridou, E.; Gooljar, S.B.; Chapple, J.P. From hatching to dispatching: The multiple cellular roles of the hsp70 molecular chaperone machinery. J. Mol. Endocrinol. 2009, 42, 1-9.
• Mogk, A.; Bukau, B. Molecular chaperones: Structure of a protein disaggregase. Curr. Biol. 2003, 14, R78-R80.
• Daugaard, M.; Rohde, M.; Jaattela, M. The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions. FEBS Lett. 2007, 581, 3702-3710.

Terms in the title (7)： 基質 ,  ドメイン ,  コミュニケーション ,  ヒト ,  HSP70 ,  結合ドメイン ,  立体配座