Art

J-GLOBAL ID：201902268344866965   Reference number：19A2156081

Screening of new therapeutic compounds for tuberous sclerosis complex

結節性硬化症に対する新しい治療薬の探索

Author (3)： YAMAGATA KANATO (東京都医学研総合研) ,  SHIMADA TADAYUKI (東京都医学研総合研) ,  SUGIURA HIROKO (東京都医学研総合研)
Material： てんかん治療研究振興財団研究年報  (Annual Report of the Japan Epilepsy Research Foundation)
Volume： 30  Page： 57-64  Publication year： Sep. 01, 2019 
JST Material Number： J1276A  ISSN： 0915-5902  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： hereditary disease ,...
Semi thesaurus term： genetic variation ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=19A2156081&from=J-GLOBAL&jstjournalNo=J1276A") }}

JST classification (1)： Basic neurology  (GN01020W)

Reference (13)：

• Yamagata K, Sanders LK, Kaufmann WE, Yee W, Barnes CA, Nathans D, et al. rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein. J Biol Chem 1994 ; 269 : 16333-16339.
• Crino PB, Nathanson KL, Henske EP. The tuberous sclerosis complex. N Engl J Med 2006 ; 355 : 1345-1356.
• Krueger DA, Wilfong AA, Holland-Bouley K, Anderson AE, Agricola K, Tudor C, et al. Everolimus treatment of refractory epilepsy in tuberous sclerosis complex. Ann Neurol 2013 ; 74 : 679-687.
• Krueger DA, Sadhwani A, Byars AW, de Vries PJ, Franz DN, Whittemore VH, et al. Everolimus for treatment of tuberous sclerosis complex-associated neuropsychiatric disorders. Ann Clin Transl Neurol 2017 ; 4 : 877-887.
• Ehninger D, Han S, Shilyansky C, Zhou Y, Li W, Kwiatkowski DJ, et al. Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis. Nat Med 2008 ; 14 : 843-848.

Terms in the title (3)： 結節性硬化症 ,  治療薬 ,  探索