Art

J-GLOBAL ID：201902268804399278   Reference number：19A0627733

Ruthenium(II) salicylate complexes inducing ROS-mediated apoptosis by targeting thioredoxin reductase

チオレドキシンレダクターゼ標的化によるROS媒介アポトーシスを誘導するルテニウム(II)サリチル酸錯体【JST・京大機械翻訳】

Author (11)： Chen Jin-can (Analysis Centre of Guangdong Medical University, Zhanjiang 524023, China) ,  Chen Jin-can (Guangdong Key Laboratory for Research and Development of Nature Drugs, Guangdong Medical University, Zhanjiang 524023, China) ,  Zhang Yao (Dongguan Key Laboratory of Drug Design and Formulation Technology, School of Pharmacy, Guangdong Medical University, Dongguan 523808, China) ,  Jie Xin-ming (Analysis Centre of Guangdong Medical University, Zhanjiang 524023, China) ,  She Ji (Dongguan Key Laboratory of Drug Design and Formulation Technology, School of Pharmacy, Guangdong Medical University, Dongguan 523808, China) ,  Dongye Guang-zhi (Analysis Centre of Guangdong Medical University, Zhanjiang 524023, China) ,  Zhong Yu (Analysis Centre of Guangdong Medical University, Zhanjiang 524023, China) ,  Deng Yuan-yuan (Dongguan Key Laboratory of Drug Design and Formulation Technology, School of Pharmacy, Guangdong Medical University, Dongguan 523808, China) ,  Wang Jie (Dongguan Key Laboratory of Drug Design and Formulation Technology, School of Pharmacy, Guangdong Medical University, Dongguan 523808, China) ,  Guo Bo-yang (The First Clinical Medical College, Guangdong Medical University, Zhanjiang 524023, China) ,  Chen Lan-mei (Dongguan Key Laboratory of Drug Design and Formulation Technology, School of Pharmacy, Guangdong Medical University, Dongguan 523808, China)
Material： Journal of Inorganic Biochemistry  (J Inorg Biochem)
Volume： 193  Page： 112-123  Publication year： 2019 
JST Material Number： D0908A  ISSN： 0162-0134  CODEN： JIBID  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Thioredoxin reductase (TrxR), ...

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Thesaurus term： tumor cell ,  antitumor action ,  complex(substance) ,  oxidative stress ,  cellular signal transduction ,  *thioredoxin reductase ,  human(primates) ,  *thioredoxin ,  cisplatin ,  *apoptosis ,  A549 cell ,  *targeting ,  aromatic carboxylic acid ,  phenolic compound ,  hydroxy acid
Semi thesaurus term： 正常細胞 ,  過剰発現 , 【Automatic Indexing@JST】

Author keywords (5)： Ru (II) complexes ,  Salicylate ,  Apoptosis ,  Thioredoxin reductase ,  ROS

JST classification (1)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (1)： Salicylic Acid

Terms in the title (8)： チオレドキシンレダクターゼ ,  標的化 ,  ROS ,  アポトーシス ,  誘導 ,  ルテニウム ,  サリチル酸 ,  錯体