Art
J-GLOBAL ID：201902269286373580   Reference number：19A2305201

Reduced Extracellular Matrix Stiffness Prompts SH-SY5Y Cell Softening and Actin Turnover To Selectively Increase Aβ(1-42) Endocytosis

細胞外マトリックス剛性の低下はSH-SY5Y細胞軟化とアクチン代謝回転を促進し,Aβ_(1-42)エンドサイトーシスを選択的に増加させる【JST・京大機械翻訳】
Author (6)：
Kruger Terra M.

About Kruger Terra M.

(Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa, United States)

About Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa, United States

, 
Bell Kendra J.

About Bell Kendra J.

(Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa, United States)

About Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa, United States

, 
Lansakara Thiranjeewa I.

About Lansakara Thiranjeewa I.

(Department of Chemistry, The University of Iowa, Iowa, United States)

About Department of Chemistry, The University of Iowa, Iowa, United States

, 
Tivanski Alexei V.

About Tivanski Alexei V.

(Department of Chemistry, The University of Iowa, Iowa, United States)

About Department of Chemistry, The University of Iowa, Iowa, United States

, 
Doorn Jonathan A.

About Doorn Jonathan A.

(Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa, United States)

About Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa, United States

, 
Stevens Lewis L.

About Stevens Lewis L.

(Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa, United States)

About Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa, United States


Material：
ACS Chemical Neuroscience

About ACS Chemical Neuroscience


Volume： 10  Issue： 3  Page： 1284-1293  Publication year： 2019 
JST Material Number： W5038A  ISSN： 1948-7193  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)
Abstract/Point：
Abstract/Point
Japanese summary of the article(about several hundred characters).
All summary is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
Alzheimer’s disease (AD), the ...
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Thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
*endocytosis

About endocytosis

, 
plaque

About plaque

, 
human(primates)

About human(primates)

, 
plastic

About plastic

, 
peptide

About peptide

, 
lysosome

About lysosome

, 
deposition

About deposition

, 
*rigidity

About rigidity

, 
integrin

About integrin

, 
therapy

About therapy

, 
sensitivity

About sensitivity

, 
*extracellular matrix

About extracellular matrix

, 
*actin

About actin

, 
amyloid beta-protein

About amyloid beta-protein

, 
Alzheimer disease

About Alzheimer disease


Semi thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
アイソフォーム

About アイソフォーム

, 【Automatic Indexing@JST】
Author keywords (6)：
Amyloid

About Amyloid

, 
endocytosis

About endocytosis

, 
cell stiffness

About cell stiffness

, 
extracellular matrix

About extracellular matrix

, 
Alzheimer’s disease

About Alzheimer’s disease

, 
mechanosensitive

About mechanosensitive

JST classification (1)：
JST classification
Category name(code) classified by JST.
Basic neurology 
(GN01020W)

About Basic neurology

Terms in the title (8)：
Terms in the title
Keywords automatically extracted from the title.
細胞外マトリックス

About 細胞外マトリックス

, 
剛性

About 剛性

, 
SH-SY5Y細胞

About SH-SY5Y細胞

, 
軟化

About 軟化

, 
アクチン

About アクチン

, 
代謝回転

About 代謝回転

, 
促進

About 促進

, 
エンドサイトーシス

About エンドサイトーシス


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