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J-GLOBAL ID：201902269727375304   Reference number：19A1324098

High-Molecular-Weight Hyaluronan Is a Hippo Pathway Ligand Directing Cell Density-Dependent Growth Inhibition via PAR1b

高分子量ヒアルロナンは,PAR1Bを介して細胞密度依存性増殖阻害を指向するHippo経路リガンドである【JST・京大機械翻訳】

Author (5)： Ooki Takuya (Division of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan) ,  Murata-Kamiya Naoko (Division of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan) ,  Takahashi-Kanemitsu Atsushi (Division of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan) ,  Wu Weida (Division of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan) ,  Hatakeyama Masanori (Division of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan)
Material： Developmental Cell  (Dev Cell)
Volume： 49  Issue： 4  Page： 590-604.e9  Publication year： 2019 
JST Material Number： W1692A  ISSN： 1534-5807  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： High-molecular-weight hyaluron...

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Thesaurus term： complex(substance) ,  clustering ,  breast tumor ,  polarity ,  biological activity ,  heterotrans plantation ,  *inhibition of multiplication ,  *hyaluronic acid ,  prognosis ,  cellular signal transduction ,  CD44 antigen ,  extracellular matrix ,  tumorigenesis
Semi thesaurus term： ドメイン構造 ,  *Hippo蛋白質 , 【Automatic Indexing@JST】

Author keywords (7)： CD44 ,  high-molecular-weight hyaluronan ,  Hippo signal ,  low-molecular-weight hyaluronan ,  hyaluronidase-2 ,  PAR1b ,  triple-negative breast cancer

JST classification (2)： Cell physiology in general  (EF02010S) ,  Biological function  (EB03040U)

Terms in the title (5)： 高分子量 ,  ヒアルロナン ,  阻害 ,  Hippo経路 ,  リガンド