Art

J-GLOBAL ID：201902270966708713   Reference number：19A1699539

Development of the simultaneous LC/MS/MS analysis method for donepezil and memantine in the serum of patients with Alzheimer’s disease

アルツハイマー病患者の血清におけるドネペジルとメマンチンのLC/MS/MS解析法の開発

Author (6)： NAKAMURA Tomohisa (Mie Prefectural Mental Medical Center, Mie, JPN) ,  NAKAMURA Tomohisa (Suzuka Univ. Medical Sci., Mie, JPN) ,  FUJISAWA Yutaka (Suzuka Univ. Medical Sci., Mie, JPN) ,  MORIKAWA Masayuki (Mie Prefectural Mental Medical Center, Mie, JPN) ,  KAWANISHI Shosuke (Suzuka Univ. Medical Sci., Mie, JPN) ,  MIWA Takaichi (Suzuka Univ. Medical Sci., Mie, JPN)
Material： 医薬品安全性学  (日本医薬品安全性学会会誌)
Volume： 3  Issue： 1  Page： 29-42  Publication year： Jul. 14, 2017 
JST Material Number： F2284A  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *LC-MS analysis ,...
Semi thesaurus term： *LC/MS/MS

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JST classification (2)： Clinical biopharmacy  (GY01022L) ,  Drug therapy(=pharmacotherapy)for mental disorders  (GR04020D)

Substance index (2)： Donepezil ,  Memantine

Reference (19)：

• Tariot PN, Farlow MR, Grossberg GT, Graham SM, McDonald S, Gergel I; Memantine study group. Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: A randomized controlled trial. JAMA 2004; 291: 317-324.
• Miyamura T, Yasuda A, Kinoshita T, Motonaga T, Nakano S, Hirai S, Oosawa M, Kawashima N, Kawabata N, Takakuwa M, Takase Y, Takita M, Narabayashi Y, Hachtmori A, Hirahara S, Ikeda E, Hashimoto M, Ikeda M, Asada T, Kosaka K. Fact-finding survey on inappropriate drug prescriptions for behavioral and psychological symptoms of dementia (BPSD). Japanese journal of geriatric psychiatry 2012; 3: 63-73.
• Spanagel R, Eilbacher B, Wilke R. Memantine-induced dopamine release in the prefronta cortex and striatum of the rat-a pharmacokinetic microdialysis study. Eur J Pharmacol 1994; 262: 21-26.
• Moritoyo T, Hasunuma T, Harada K, Tateishi T, Watanabe M, Kotegawa T, Nagai M, Kumagai Y, Fujitani T, Okura T, Fukuoka T, Miyoshi K, Matsuura B, Furukawa S, Kobori T, Moritoyo H, Nishikawa N, Tsujii T, Iwaki H, Nakamura M, Makino S, Ohnuma K, Yuji K, Hashimoto M, Takasu M, Hashizume Y, You K, Matsumura T, Tanaka Y, Matsumoto N, Nakamura J, Miura J, Akizawa T, Kitazawa K, Shibata T, Kuroki A, Honda H, Mukai M, Ohashi K, Morimoto T, Imai H, Okudaira T, Sato F, Imanaga J, Tanaka K, Nomoto M. Effect of renal impairment on the pharmacokinetics of memantine. J Pharmacol Sci 2012; 119: 324-329.
• Suresh P, Ramesh M, Sathesh K. Highly sensitive LC-MS/MS method for determination of memantine in rat plasma: Application to pharmacokinetic studies in rats, Indian Journal of Pharmaceutical Education and Research, 2014; 48: 54-65.

Terms in the title (7)： アルツハイマー病 ,  患者 ,  血清 ,  ドネペジル ,  メマンチン ,  解析法 ,  開発