Art

J-GLOBAL ID：201902271127786663   Reference number：19A1751381

In vitro bile acid-dependent hepatocyte toxicity assay system using human induced pluripotent stem cell-derived hepatocytes: Current status and disadvantages to overcome

ヒト人工多能性幹細胞由来肝細胞を用いたin vitro胆汁酸依存性肝細胞毒性試験システム:現状と克服すべき欠点

Author (8)： Sakai Yoko (Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan) ,  Iwao Takahiro (Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan) ,  Susukida Takeshi (The Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan) ,  Nukaga Takumi (The Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan) ,  Takemura Akinori (The Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan) ,  Sekine Shuichi (The Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan) ,  Ito Kousei (The Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan) ,  Matsunaga Tamihide (Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan)
Material： Drug Metabolism and Pharmacokinetics (Web)  (Drug Metab Pharmacokinet (Web))
Volume： 34  Issue： 4  Page： 264-271  Publication year： 2019 
JST Material Number： U0705A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： hepatocyte ,...
Semi thesaurus term： BSEP ,...

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Author keywords (5)： Bile acid ,  Cholestatic drug-induced liver injury ,  Human induced pluripotent stem cell ,  Multidrug resistance-associated protein ,  Sandwich-cultured hepatocyte model

JST classification (1)： Research methods  (GV01020U)

Terms in the title (8)： ヒト ,  人工多能性幹細胞 ,  肝細胞 ,  胆汁酸 ,  依存性 ,  毒性試験 ,  現状 ,  欠点