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J-GLOBAL ID：201902271232523514   Reference number：19A1806513

The Mechanism of Regulation of Pantothenate Biosynthesis by the PanD-PanZ・AcCoA Complex Reveals an Additional Mode of Action for the Antimetabolite N-Pentyl Pantothenamide (N5-Pan)

pand-panz ・acCoA複合体によるパントテン酸生合成の調節機構は抗代謝産物N-ペンチルパントテナミド(N5-PAN)に対する付加的作用様式を明らかにする【JST・京大機械翻訳】

Author (10)： Arnott Zoe L. P. (Astbury Centre for Structural Molecular Biology and School of Chemistry, University of Leeds, U.K.) ,  Arnott Zoe L. P. (Hamburg Center for Ultrafast Imaging, Institute of Nanostructure and Solid State Physics, University of Hamburg, Germany) ,  Nozaki Shingo (Microbial Genetics Laboratory, Genetics Strains Research Center, National Institute of Genetics, Japan) ,  Monteiro Diana C. F. (Astbury Centre for Structural Molecular Biology and School of Chemistry, University of Leeds, U.K.) ,  Monteiro Diana C. F. (Hamburg Center for Ultrafast Imaging, Institute of Nanostructure and Solid State Physics, University of Hamburg, Germany) ,  Morgan Holly E. (Astbury Centre for Structural Molecular Biology and School of Chemistry, University of Leeds, U.K.) ,  Pearson Arwen R. (Hamburg Center for Ultrafast Imaging, Institute of Nanostructure and Solid State Physics, University of Hamburg, Germany) ,  Niki Hironori (Microbial Genetics Laboratory, Genetics Strains Research Center, National Institute of Genetics, Japan) ,  Niki Hironori (Department of Genetics, Graduate University for Advanced Studies (Sokendai), Japan) ,  Webb Michael E. (Astbury Centre for Structural Molecular Biology and School of Chemistry, University of Leeds, U.K.)
Material： Biochemistry
Volume： 56  Issue： 37  Page： 4931-4939  Publication year： 2017 
JST Material Number： B0270B  ISSN： 0006-2960  CODEN： BICHAW  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： The antimetabolite pentyl pant...

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Thesaurus term： cofactor ,  spectrum ,  coenzyme ,  *complex (substance) ,  ketone ,  *metabolite ,  antibiotics ,  *biosynthesis ,  carboxy-lyase ,  Escherichia coli ,  overexpression ,  Biosynthetic Pathways ,  antibacterial drug ,  antimicrobial drug ,  drug ,  microorganism ,  aliphatic ketone ,  aliphatic carboxylic acid ,  keto acid ,  aliphatic amine ,  aliphatic alcohol ,  carboxamide ,  aminocarboxylic acid ,  diol ,  secondary alcohol ,  hydroxy acid

JST classification (1)： Enzyme in general  (EB09010D)

Substance index (3)： Pyruvic Acid ,  β-Alanine ,  Pantothenic Acid

Terms in the title (7)： 複合体 ,  パントテン酸 ,  生合成 ,  調節 ,  代謝産物 ,  PAN ,  作用様式