Art

J-GLOBAL ID：201902271454111165   Reference number：19A0079814

Targeting PKCδ as a Therapeutic Strategy against Heterogeneous Mechanisms of EGFR Inhibitor Resistance in EGFR-Mutant Lung Cancer

EGFR変異体肺癌におけるEGFR阻害剤耐性の不均一機構に対する治療戦略としてのターゲティングδδ【JST・京大機械翻訳】

Author (59)： Lee Pei-Chih (Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Fang Yueh-Fu (Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Fang Yueh-Fu (Department of Thoracic Medicine, Chang Gung Foundation, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan) ,  Fang Yueh-Fu (Department of Pulmonary and Critical Care Medicine Saint Paul’s Hospital, Taoyuan City 33069, Taiwan) ,  Fang Yueh-Fu (College of Medicine, Chang Gung University, Taoyuan 333, Taiwan) ,  Yamaguchi Hirohito (Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Wang Wei-Jan (Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Chen Tse-Ching (College of Medicine, Chang Gung University, Taoyuan 333, Taiwan) ,  Chen Tse-Ching (Department of Pathology, Chang Gung Foundation, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan) ,  Hong Xuan (Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Hong Xuan (Thoracic Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150081, China) ,  Ke Baozhen (Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Xia Weiya (Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Wei Yongkun (Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Zha Zhengyu (Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Wang Yan (Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Kuo Han-Pin (Department of Thoracic Medicine, Chang Gung Foundation, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan) ,  Kuo Han-Pin (College of Medicine, Chang Gung University, Taoyuan 333, Taiwan) ,  Wang Chih-Wei (College of Medicine, Chang Gung University, Taoyuan 333, Taiwan) ,  Wang Chih-Wei (Department of Pathology, Chang Gung Foundation, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan) ,  Tu Chih-Yen (Division of Pulmonary and Critical Care Medicine, China Medical University and Hospital, Taichung 404, Taiwan) ,  Tu Chih-Yen (Department of Internal Medicine, China Medical University and Hospital, Taichung 404, Taiwan) ,  Tu Chih-Yen (School of Medicine, China Medical University, Taichung 404, Taiwan) ,  Tu Chih-Yen (Department of Life Science, National Chung-Hsing University, Taichung 402, Taiwan) ,  Chen Chia-Hung (Division of Pulmonary and Critical Care Medicine, China Medical University and Hospital, Taichung 404, Taiwan) ,  Chen Chia-Hung (Department of Internal Medicine, China Medical University and Hospital, Taichung 404, Taiwan) ,  Chen Chia-Hung (Department of Respiratory Therapy, China Medical University, Taichung 404, Taiwan) ,  Chen Chia-Hung (Graduate Institute of Clinical Medical Science, China Medical University, Taichung 404, Taiwan) ,  Huang Wei-Chien (Center for Molecular Medicine and Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan) ,  Huang Wei-Chien (Department of Biotechnology, Asia University, Taichung 413, Taiwan) ,  Chiang Shu-Fen (Cancer Center, China Medical University, Taichung 404, Taiwan) ,  Nie Lei (Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Hou Junwei (Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Chen Chun-Te (Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Huo Longfei (Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Yang Wen-Hao (Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Deng Rong (Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Deng Rong (State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China) ,  Nakai Katsuya (Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Hsu Yi-Hsin (Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Chang Shih-Shin (Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Chiu Tai-Jan (Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Chiu Tai-Jan (Department of Medical Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 333, Taiwan) ,  Tang Jun (Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Tang Jun (State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China) ,  Zhang Ran (Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Wang Li (Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Fang Bingliang (Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Chen Ting (Division of Hematology & Medical Oncology, Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY 10016, USA) ,  Chen Ting (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA) ,  Wong Kwok-Kin (Division of Hematology & Medical Oncology, Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY 10016, USA) ,  Wong Kwok-Kin (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA) ,  Wong Kwok-Kin (Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA) ,  Hsu Jennifer L. (Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Hsu Jennifer L. (Center for Molecular Medicine and Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan) ,  Hsu Jennifer L. (Department of Biotechnology, Asia University, Taichung 413, Taiwan) ,  Hung Mien-Chie (Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Hung Mien-Chie (Center for Molecular Medicine and Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan) ,  Hung Mien-Chie (Department of Biotechnology, Asia University, Taichung 413, Taiwan)
Material： Cancer Cell
Volume： 34  Issue： 6  Page： 954-969.e4  Publication year： 2018 
JST Material Number： W1844A  ISSN： 1535-6108  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Multiple mechanisms of resista...

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Thesaurus term： membrane receptor ,  *therapeutic planning ,  tumor ,  recurrence ,  *targeting ,  *EGF receptor ,  *lung tumor ,  inactivation ,  mutation ,  heterogeneity ,  dimerization ,  non-small cell lung cancer
Semi thesaurus term： 耐性機構 ,  チロシンキナーゼ阻害剤 ,  *EGFRチロシンキナーゼ阻害剤 , 【Automatic Indexing@JST】

Author keywords (10)： lung cancer ,  EGFR ,  PKCδ ,  PKC delta ,  tyrosine kinase inhibitor ,  TKI ,  resistance ,  heterogeneity ,  heterogeneous mechanism of TKI resistance ,  heterogeneous resistance

JST classification (2)： Tumors(=neoplasms)of respiratory system  (GI04000G) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Terms in the title (8)： EGFR ,  変異体 ,  肺癌 ,  EGFR阻害剤 ,  耐性 ,  不均一 ,  治療戦略 ,  ターゲティング