Art

J-GLOBAL ID：201902271559756413   Reference number：19A1303473

Synaptic functions and their disruption in schizophrenia: From clinical evidence to synaptic optogenetics in an animal model

統合失調症におけるシナプス機能とそれらの混乱 動物モデルにおける臨床的証拠からシナプス光遺伝学まで

Author (4)： OBI-NAGATA Kisho (Laboratory of Medical Neuroscience, Institute for Molecular and Cellular Regulation, Gunma University) ,  TEMMA Yusuke (Laboratory of Medical Neuroscience, Institute for Molecular and Cellular Regulation, Gunma University) ,  HAYASHI-TAKAGI Akiko (Laboratory of Medical Neuroscience, Institute for Molecular and Cellular Regulation, Gunma University) ,  HAYASHI-TAKAGI Akiko (PRESTO, Japan Science and Technology Agency)
Material： Proceedings of the Japan Academy. Series B. Physical and Biological Sciences  (日本学士院紀要 B)
Volume： 95  Issue： 5  Page： 179-197(J-STAGE)  Publication year： 2019 
JST Material Number： G0485B  ISSN： 0386-2208  CODEN： PJABDW  Document type： Article
Article type： 文献レビュー  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *schizophrenia ,...
Semi thesaurus term： *nerve synapses ,...

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Author keywords (5)： synaptopathy ,  schizophrenia ,  synaptic integration ,  optogenetics ,  AS-PaRac1

JST classification (2)： Mental disorders  (GR03000A) ,  Central nervous system  (EJ12030F)

Reference (112)：

• 1) Birnbaum, R. and Weinberger, D.R. (2017) Genetic insights into the neurodevelopmental origins of schizophrenia. Nat. Rev. Neurosci. 18, 727-740.
• 2) Sjostrom, P.J., Rancz, E.A., Roth, A. and Hausser, M. (2008) Dendritic excitability and synaptic plasticity. Physiol. Rev. 88, 769-840.
• 3) Meyer-Lindenberg, A. and Weinberger, D.R. (2006) Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nat. Rev. Neurosci. 7, 818-827.
• 4) Fino, E., Packer, A.M. and Yuste, R. (2013) The logic of inhibitory connectivity in the neocortex. Neuroscientist 19, 228-237.
• 5) Yuste, R. (2011) Dendritic spines and distributed circuits. Neuron 71, 772-781.

Terms in the title (8)： 統合失調症 ,  シナプス ,  混乱 ,  動物 ,  モデル ,  臨床 ,  証拠 ,  光遺伝学