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J-GLOBAL ID：201902273128118685   Reference number：19A2733737

Exposure to valproic acid during middle to late-stage corticogenesis induces learning and social behavioral abnormalities with attention deficit/hyperactivity in adult mice

成体マウスにおける中期から後期の皮質形成の間のバルプロ酸への曝露により,注意欠陥/多動性を伴う学習および社会的行動異常を誘発する

Author (5)： SAKADE Yuki (Laboratory of Molecular Biology, Department of Biofunctional Analysis, Gifu Pharmaceutical University) ,  YAMANAKA Kumiko (Laboratory of Molecular Biology, Department of Biofunctional Analysis, Gifu Pharmaceutical University) ,  SOUMIYA Hitomi (Laboratory of Molecular Biology, Department of Biofunctional Analysis, Gifu Pharmaceutical University) ,  FURUKAWA Shoei (Laboratory of Molecular Biology, Department of Biofunctional Analysis, Gifu Pharmaceutical University) ,  FUKUMITSU Hidefumi (Laboratory of Molecular Biology, Department of Biofunctional Analysis, Gifu Pharmaceutical University)
Material： Biomedical Research (Web)
Volume： 40  Issue： 5  Page： 179-188(J-STAGE)  Publication year： 2019 
JST Material Number： U1102A  ISSN： 1880-313X  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Mus musculus ,...
Semi thesaurus term： Abnormal behavior ,...

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JST classification (2)： Basic neurology  (GN01020W) ,  Congenital diseases,deformities in general.  (GD03010V)

Substance index (1)： Valproic acid

Reference (44)：

• 1 American Psychiatric Association (2013) Diagnostic and Statistical Manual of Mental Disorders (DSM-5). 5th edn., VA: American Psychiatric Association, Arlington.
• 2 Auger ML and Floresco SB (2014) Prefrontal cortical GABA modulation of spatial reference and working memory. Int J Neuropsychopharmacol 18, pyu013.
• 3 Beck SL (2001) Does genomic imprinting contribute to valproic acid teratogenicity? Reprod Toxicol 15, 43-48.
• 4 Bell SB and DeWall N (2018) Does transcranial direct current stimulation to the prefrontal cortex affect social behavior? A meta-analysis. Soc Cogn Affect Neurosci 13, 899-906.
• 5 Betancur C (2011) Etiological heterogeneity in autism spectrum disorders: more than 100 genetic and genomic disorders and still counting. Brain Res 1380, 42-77.

Terms in the title (11)： 成体 ,  マウス ,  中期 ,  皮質 ,  バルプロ酸 ,  曝露 ,  注意 ,  欠陥 ,  学習 ,  社会的行動 ,  誘発