Art

J-GLOBAL ID：201902274147495357   Reference number：19A1129782

Structural requirements of cholenamide derivatives as the LXR ligands

LXRリガンドとしてのコレナミド誘導体の構造要件【JST・京大機械翻訳】

Author (10)： Saida-Tamiya Kana (Department of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima, Akiha-ku, Niigata 956-8603, Japan) ,  Tamiya Minoru (Department of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima, Akiha-ku, Niigata 956-8603, Japan) ,  Sekiya Genki (Department of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima, Akiha-ku, Niigata 956-8603, Japan) ,  Isobe Kazunori (Department of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima, Akiha-ku, Niigata 956-8603, Japan) ,  Kitazawa Takaaki (Department of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima, Akiha-ku, Niigata 956-8603, Japan) ,  Isaka Nobuhisa (Department of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima, Akiha-ku, Niigata 956-8603, Japan) ,  Matsukawa Ayako (Department of Biochemistry, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima, Akiha-ku, Niigata 956-8603, Japan) ,  Kawahara Kohichi (Department of Biochemistry, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima, Akiha-ku, Niigata 956-8603, Japan) ,  Komuro Akihiko (Department of Biochemistry, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima, Akiha-ku, Niigata 956-8603, Japan) ,  Ishiguro Masaji (Department of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima, Akiha-ku, Niigata 956-8603, Japan)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 29  Issue： 11  Page： 1330-1335  Publication year： 2019 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： A study of the structural requ...

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Thesaurus term： hydrogen bond ,  *hydrophobic ,  isomer (molecule) ,  stereochemistry ,  affinity ,  gene ,  determination factor ,  Trans-Activation (Genetics) ,  effect concentration 50 ,  bile acid ,  alicyclic alcohol ,  secondary alcohol ,  polyol
Semi thesaurus term： 残基 ,  複合化 , 【Automatic Indexing@JST】

Author keywords (5)： LXR ,  Cholic acid ,  24 25-Epoxycholesterol ,  N N-Dimethylcholenamide ,  Molecular modeling

JST classification (2)： Synthesis of drugs  (GV01030F) ,  Structure-activity relationship of drugs  (GV01050B)

Substance index (1)： Cholic acid

Terms in the title (3)： LXR ,  リガンド ,  誘導体