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J-GLOBAL ID：201902275404121744   Reference number：19A1567277

Peppermint (Mentha piperita L.) extract effectively inhibits cytochrome P450 3A4 (CYP3A4) mRNA induction in rifampicin-treated HepG2 cells

セイヨウハッカ(Mentha piperita L.)抽出液はリファンピシン処理HepG2細胞におけるチトクロームP450 3A4(CYP3A4)mRNA誘導を効果的に阻害する

Author (5)： KOBAYASHI Tsukasa (Tokyo Univ. Agriculture, Tokyo, JPN) ,  KOBAYASHI Tsukasa (St. Marianna Univ. School of Medicine, Kawasaki, JPN) ,  SUGAYA Kouichi (Tokyo Univ. Agriculture, Tokyo, JPN) ,  ONOSE Jun-Ichi (Tokyo Univ. Agriculture, Tokyo, JPN) ,  ABE Naoki (Tokyo Univ. Agriculture, Tokyo, JPN)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 83  Issue： 7  Page： 1181-1192  Publication year： Jul. 2019 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *cytochrome P450 ,...
Semi thesaurus term： *CYP3A4 ,...

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JST classification (3)： Gene expression  (EC02040Q) ,  Food chemistry,nutritional value  (FJ01020J) ,  Basic research of antibiotics acting on pathogenic organisms  (GX05020C)

Substance index (2)： Pheophorbide a ,  Rifampin

Reference (25)：

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• Paine MF, Hart HL, Ludington SS, et al. The human intestinal cytochrome P450 “pie”. Drug Metab Dispos. 2006;34:880-886.
• Zanger UM, Schwab M. Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol Ther. 2013;138:103-141.
• Hirata-Koizumi M, Saito M, Urano T, et al. Improvement of package insert CYP information for prescription drugs marketed in Japan. Bull Natl Inst Health Sci. 2005;123:12-18.
• Gurley BJ, Gardner SF, Hubbard MA, et al. Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans. Clin Pharmacol Ther. 2002;72:276-287.

Terms in the title (10)： セイヨウハッカ ,  Mentha ,  抽出液 ,  リファンピシン ,  HepG2細胞 ,  チトクロームP450 ,  CYP3A4 ,  mRNA ,  誘導 ,  阻害