Art

J-GLOBAL ID：201902276081724777   Reference number：19A0768012

Potential Use of Magnesium Oxide as an Excipient to Maintain the Hardness of Orally Disintegrating Tablets during Unpackaged Storage

非包装貯蔵中の経口崩壊錠の硬度を維持するための賦形剤としての酸化マグネシウムの利用可能性

Author (4)： Sakamoto Takatoshi (Department of Pharmaceutical Technology, School of Clinical Pharmacy, College of Pharmaceutical Sciences, Matsuyama University) ,  Kachi Shigeto (Pharmaceuticals Division, Kyowa Chemical Industry Co., Ltd.) ,  Nakamura Shohei (Department of Pharmaceutical Technology, School of Clinical Pharmacy, College of Pharmaceutical Sciences, Matsuyama University) ,  Yuasa Hiroshi (Department of Pharmaceutical Technology, School of Clinical Pharmacy, College of Pharmaceutical Sciences, Matsuyama University)
Material： Chemical and Pharmaceutical Bulletin (Web)
Volume： 67  Issue： 3  Page： 284-288(J-STAGE)  Publication year： 2019 
JST Material Number： U1401A  ISSN： 1347-5223  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *tablet(pharmaceuticals) ,...
Semi thesaurus term： *Pharmaceutical Vehicles ,...

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Author keywords (8)： orally disintegrating tablet ,  relative humidity ,  unpackaged state ,  dissolution test ,  orally disintegrating tablet ,  relative humidity ,  unpackaged state ,  dissolution test

JST classification (2)： Solid preparations  (GY02030V) ,  Physicochemical characteristics of drugs  (GV01060M)

Substance index (1)： Acetaminophen

Reference (13)：

• 1) U. S. Food and Drug Administration, Center for Drug Evaluation and Research, “Guidance for Industry Orally Disintegrating Tablets, 2008.”: ‹http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatory/Information/Guidances/ucm070578.pdf›, cited 18 December, 2008.
• 2) Hinari J. J., Rathod D. A., Vadalia K. R., Trop. J. Pharm. Res., 8, 161-172 (2009).
• 3) Bandari S., Mittapalli R., Gannu R., Rao Y. M., Asian J. Pharm., 2, 2-11 (2008).
• 4) Al-khattawi A., Mohammed A. R., Expert Opin. Drug Deliv., 10, 651-663 (2013).
• 5) Pandey P., Dahiya M., Int. J. Pharma Res. Rev., 5, 50-62 (2016).

Terms in the title (7)： 包装 ,  貯蔵 ,  経口崩壊錠 ,  硬度 ,  賦形剤 ,  酸化マグネシウム ,  利用可能性