Art

J-GLOBAL ID：201902276133139560   Reference number：19A0785046

Integrated biology approach reveals molecular and pathological interactions among Alzheimer’s Aβ42, Tau, TREM2, and TYROBP in Drosophila models

統合生物学的アプローチはショウジョウバエモデルにおけるAlzheimerのAβ42,タウ,TREM2およびチロBP間の分子的および病理学的相互作用を明らかにする【JST・京大機械翻訳】

Author (25)： Sekiya Michiko (Department of Alzheimer’s Disease Research, National Center for Geriatrics and Gerontology, Obu, Japan) ,  Wang Minghui (Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA) ,  Wang Minghui (Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, USA) ,  Fujisaki Naoki (Department of Alzheimer’s Disease Research, National Center for Geriatrics and Gerontology, Obu, Japan) ,  Fujisaki Naoki (Department of Experimental Gerontology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan) ,  Sakakibara Yasufumi (Department of Alzheimer’s Disease Research, National Center for Geriatrics and Gerontology, Obu, Japan) ,  Quan Xiuming (Department of Alzheimer’s Disease Research, National Center for Geriatrics and Gerontology, Obu, Japan) ,  Ehrlich Michelle E. (Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA) ,  Ehrlich Michelle E. (Department of Neurology, Alzheimer’s Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, USA) ,  Ehrlich Michelle E. (Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, USA) ,  Jager Philip L. De (Center for translational & Computational Neuroimmunology, Department of Neurology, The Neurological Institute of New York, Columbia University Medical Center, New York, USA) ,  Jager Philip L. De (Broad Institute, Cambridge, USA) ,  Bennett David A. (Rush Alzheimer’s Disease Research Center and Department of Neurology, Rush University Medical Center, Chicago, USA) ,  Schadt Eric E. (Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA) ,  Schadt Eric E. (Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, USA) ,  Gandy Sam (Department of Neurology, Alzheimer’s Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, USA) ,  Gandy Sam (Department of Psychiatry and Alzheimer’s Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, USA) ,  Gandy Sam (Center for NFL Neurological Care, Department of Neurology, New York, USA) ,  Gandy Sam (James J. Peters VA Medical Center, New York, USA) ,  Ando Kanae (Department of Biological Sciences, Graduate School of Science and Engineering, Tokyo Metropolitan University, Tokyo, Japan) ,  Zhang Bin (Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA) ,  Zhang Bin (Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, USA) ,  Zhang Bin (Ronald M. Loeb Center for Alzheimer’s Disease, Icahn School of Medicine at Mount Sinai, New York, USA) ,  Iijima Koichi M. (Department of Alzheimer’s Disease Research, National Center for Geriatrics and Gerontology, Obu, Japan) ,  Iijima Koichi M. (Department of Experimental Gerontology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan)
Material： Genome Medicine (Web)
Volume： 10  Issue： 1  Page： 26  Publication year： 2018 
JST Material Number： U7320A  ISSN： 1756-994X  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Cerebral amyloidosis, neuroinf...

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Thesaurus term： Amyloid ,  network ,  Mutation ,  *interaction ,  human ,  *pathological state ,  gene ,  synapse ,  pathophysiology ,  glia cell ,  neuron ,  *Alzheimer Disease ,  *amyloid beta 42 ,  *Drosophila ,  Proteins ,  glycoprotein ,  animal protein ,  *Diptera ,  *invertebrate
Semi thesaurus term： *Drosophila ,  神経変性 , 【Automatic Indexing@JST】

Author keywords (11)： Alzheimer’s disease ,  Amyloid-β (Aβ) peptides ,  Microtubule-associated protein tau ,  TYROBP (tyrosine kinase binding protein) ,  TREM2 (triggering receptor expressed on myeloid cells 2) ,  Differential expression ,  Gene co-expression network ,  Gene module ,  Synaptophagy ,  Immune function ,  Neurodegeneration

JST classification (4)： Gene expression  (EC02040Q) ,  Genetic variation  (EC01030Y) ,  Basic psychiatry  (GR01020I) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

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Terms in the title (11)： 統合 ,  生物学 ,  ショウジョウバエ ,  モデル ,  Alzheimer ,  Aβ42 ,  TREM2 ,  BP ,  分子 ,  病理学 ,  相互作用