Art

J-GLOBAL ID：201902276185245455   Reference number：19A2870424

Carbamazepine promotes specific stimuli-induced NLRP3 inflammasome activation and causes idiosyncratic liver injury in mice

カルバマゼピンはマウスにおいて特異的刺激誘発性NLRP3インフラマソーム活性化を促進し,特異的肝損傷を引き起こす【JST・京大機械翻訳】

Author (18)： Wang Zhilei (China Military Institute of Chinese Materia, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China) ,  Wang Zhilei (School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China) ,  Xu Guang (China Military Institute of Chinese Materia, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China) ,  Zhan Xiaoyan (China Military Institute of Chinese Materia, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China) ,  Liu Youping (School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China) ,  Gao Yuan (School of Chinese Materia Medica, Capital Medical University, Beijing, China) ,  Chen Nian (School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China) ,  Guo Yuming (China Military Institute of Chinese Materia, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China) ,  Li Ruisheng (Research Center for Clinical and Translational Medicine, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China) ,  He Tingting (Integrative Medical Center, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China) ,  Song Xueai (Integrative Medical Center, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China) ,  Niu Ming (China Military Institute of Chinese Materia, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China) ,  Wang Jiabo (China Military Institute of Chinese Materia, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China) ,  Bai Zhaofang (China Military Institute of Chinese Materia, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China) ,  Bai Zhaofang (Integrative Medical Center, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China) ,  Xiao Xiaohe (China Military Institute of Chinese Materia, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China) ,  Xiao Xiaohe (School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China) ,  Xiao Xiaohe (Integrative Medical Center, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China)
Material： Archives of Toxicology
Volume： 93  Issue： 12  Page： 3585-3599  Publication year： 2019 
JST Material Number： D0867A  ISSN： 0340-5761  CODEN： ATXKA8  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： The occurrence of idiosyncrati...

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Thesaurus term： interleukin 1 ,  lipopolysaccharide ,  *hepatic dysfunction ,  active oxygen ,  pathogenesis ,  knockout mouse ,  in vitro experiment ,  anticonvulsant ,  risk factor ,  mitochondria ,  hepatocyte ,  crystal ,  human(primates) ,  caspase ,  nitrogen

Author keywords (5)： Carbamazepine ,  Hepatotoxicity ,  Caspase-1 ,  IL-1β ,  Mitochondrial reactive oxygen species

JST classification (1)： Toxicity of organic compounds  (GZ02030Y)

Terms in the title (7)： カルバマゼピン ,  マウス ,  刺激 ,  NLRP3インフラマソーム ,  活性化 ,  促進 ,  肝損傷