Art

J-GLOBAL ID：201902276606606178   Reference number：19A0768263

Histone Deacetylase Inhibitor SAHA Treatment Prevents the Development of Heart Failure after Myocardial Infarction via an Induction of Heat-Shock Proteins in Rats

ヒストン脱アセチル化酵素阻害剤SAHA治療はラットにおける熱ショック蛋白質の誘導を介して心筋梗塞後の心不全の発症を予防する

Author (3)： Nagata Shiho (Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences) ,  Marunouchi Tetsuro (Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences) ,  Tanonaka Kouichi (Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 42  Issue： 3  Page： 453-461(J-STAGE)  Publication year： 2019 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Rattus ,...
Semi thesaurus term： cardioprotective effect ,...

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Author keywords (10)： heart failure ,  histone deacetylase 6 ,  heat-shock protein ,  protein quality control ,  myocardial infarction ,  heart failure ,  histone deacetylase 6 ,  heat-shock protein ,  protein quality control ,  myocardial infarction

JST classification (3)： Basic medicine on cardiovascular system  (GJ01020K) ,  Basic research of cardioactive drugs  (GW07020N) ,  Heart  (EJ04020D)

Substance index (1)： SAHA

Reference (38)：

• 1) Willis MS, Patterson C. Proteotoxicity and cardiac dysfunction-Alzheimer’s disease of the heart? N. Engl. J. Med., 368, 455-464 (2013).
• 2) McLendon PM, Robbins J. Proteotoxicity and cardiac dysfunction. Circ. Res., 116, 1863-1882 (2015).
• 3) David R, Franz W-M. From pluripotency to distinct cardiomyocyte subtypes. Physiology, 27, 119-129 (2012).
• 4) Tsukamoto O, Minamino T, Kitakaze M. Functional alterations of cardiac proteasomes under physiological and pathological conditions. Cardiovasc. Res., 85, 339-346 (2010).
• 5) Tannous P, Zhu H, Nemchenko A, Berry JM, Johnstone JL, Shelton JM, Miller FJ Jr, Rothermel BA, Hill JA. Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy. Circulation, 117, 3070-3078 (2008).

Terms in the title (10)： ヒストン脱アセチル化酵素阻害剤 ,  SAHA ,  治療 ,  ラット ,  熱ショック蛋白質 ,  誘導 ,  心筋梗塞 ,  心不全 ,  発症 ,  予防