Art

J-GLOBAL ID：201902277167495610   Reference number：19A1782727

Radiosynthesis and evaluation of a novel monoacylglycerol lipase radiotracer: 1,1,1,3,3,3-hexafluoropropan-2-yl-3-(1-benzyl-1H-pyrazol-3-yl)azetidine-1-[¹¹C]carboxylate

新規モノアシルグリセロールリパーゼ放射性トレーサの放射性合成と評価:1,1,1,3,3,3-ヘキサフルオロプロパン-2-イル-3-(1-ベンジル-1H-ピラゾール-3-イル)アゼチジン-1-[~11C]カルボキシラート【JST・京大機械翻訳】

Author (11)： Mori Wakana (Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan) ,  Hatori Akiko (Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan) ,  Zhang Yiding (Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan) ,  Kurihara Yusuke (Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan) ,  Kurihara Yusuke (SHI Accelerator Service Co., 1-17-6 Osaki, Shinagawa-ku, Tokyo 141-0032, Japan) ,  Yamasaki Tomoteru (Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan) ,  Xie Lin (Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan) ,  Kumata Katsushi (Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan) ,  Hu Kuan (Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan) ,  Fujinaga Masayuki (Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan) ,  Zhang Ming-Rong (Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 27  Issue： 16  Page： 3568-3573  Publication year： 2019 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Monoacylglycerol lipase (MAGL)...

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Thesaurus term： Radioactivity ,  PET (tomography) ,  Hydrolysis ,  *Rattus ,  Heart ,  visualization ,  irreversibility ,  phosgene ,  Mus musculus ,  biodistribution ,  in vitro experiment ,  homogenate ,  *Monoacylglycerol Lipases ,  *Myomorpha ,  aliphatic alcohol ,  polyol
Semi thesaurus term： 阻害剤 , 【Automatic Indexing@JST】

Author keywords (5)： Monoacylglycerol lipase ,  MAGL ,  Positron emission tomography ,  [¹¹C]phosgene ,  Irreversible binding

JST classification (4)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Labeled compounds  (CB10050N) ,  Basic research of diagnostic drugs  (GW20010P) ,  Nitrogen heterocycles in general  (CF07040G)

Substance index (1)： Glycerol

Terms in the title (7)： モノアシルグリセロールリパーゼ ,  放射性トレーサ ,  放射性 ,  評価 ,  1-ベンジル-1H-ピラゾール ,  アゼチジン ,  カルボキシラート