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J-GLOBAL ID：201902278309060998   Reference number：19A1401771

SYNTHESIS AND DNA CLEAVAGE ACTIVITY OF NOVEL SPIRO[CYCLOBUTATHIAZOLE-4,4’-PYRAZOLE] DERIVATIVES

新規スピロ[シクロブタチアゾール-4,4′-ピラゾール誘導体の合成とDNA開裂活性

Author (7)： MASUMOTO Eiichi (Fukuoka Univ., Fukuoka, JPN) ,  NAGABUCHI Hayate (Fukuoka Univ., Fukuoka, JPN) ,  KASHIGE Nobuhiro (Fukuoka Univ., Fukuoka, JPN) ,  OKABE-NAKAHARA Fumi (Fukuoka Univ., Fukuoka, JPN) ,  MIAKE Fumio (Fukuoka Univ., Fukuoka, JPN) ,  YAMAGATA Kenji (Fukuoka Univ., Fukuoka, JPN) ,  MARUOKA Hiroshi (Fukuoka Univ., Fukuoka, JPN)
Material： Heterocycles  (International Journal for Reviews and Communications in Heterocyclic Chemistry)
Volume： 99  Issue： 1  Page： 669-679  Publication year： Apr. 01, 2019 
JST Material Number： S0966A  ISSN： 0385-5414  CODEN： HTCYAM  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： chemical synthesis ,  *nitrogen heterocyclic compound ,  *sulfur heterocyclic compound ,  alicyclic compound ,  Knoevenagel condensation ,  nucleophilic substitution reaction ,  cyclization reaction ,  elimination reaction ,  in vitro experiment ,  *spiro-compound ,  diketone ,  *DNA strand break ,  proton magnetic resonance ,  Thiazoles ,  Pyrazoles ,  cyclobutene derivatives ,  aromatic compound ,  vic-polynitrogen compound
Semi thesaurus term： cyclobutenes

JST classification (1)： Pyrazoles  (CF07082G)

Substance index (8)： 5',7-dimethyl-2'-phenyl-2-thia-4-azaspiro[bicyclo[3.2.0]heptane-6,4'-pyrazole]-1(7),4-diene-3,3'-dione ,  Edaravone ,  4-(3-methyl-5-oxo-1-phenylpyrazol-4-ylidene)-1,3-thiazolidin-2-one ,  5'-methyl-2',7-diphenyl-2-thia-4-azaspiro[bicyclo[3.2.0]heptane-6,4'-pyrazole]-1(7),4-diene-3,3'-dione ,  5'-methyl-2'-phenyl-7-propyl-2-thia-4-azaspiro[bicyclo[3.2.0]heptane-6,4'-pyrazole]-1(7),4-diene-3,3'-dione ,  7-ethyl-5'-methyl-2'-phenyl-2-thia-4-azaspiro[bicyclo[3.2.0]heptane-6,4'-pyrazole]-1(7),4-diene-3,3'-dione ,  7-butyl-5'-methyl-2'-phenyl-2-thia-4-azaspiro[bicyclo[3.2.0]heptane-6,4'-pyrazole]-1(7),4-diene-3,3'-dione ,  2,4-Thiazolidinedione

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Terms in the title (4)： ピラゾール誘導体 ,  DNA ,  開裂 ,  活性