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J-GLOBAL ID：201902278461712559   Reference number：19A1820882

The sodium-glucose cotransporter 2 inhibitor luseogliflozin can suppress muscle atrophy in Db/Db mice by suppressing the expression of foxo1

ナトリウム-グルコース共輸送体2阻害剤ルセオグリフロジンはFOXO1の発現を抑制することによりDb/Dbマウスにおける筋萎縮を抑制できる

Author (7)： Okamura Takuro (Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine) ,  Hashimoto Yoshitaka (Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine) ,  Osaka Takafumi (Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine) ,  Osaka Takafumi (Department of Diabetology, Ayabe City Hospital) ,  Fukuda Takuya (Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine) ,  Hamaguchi Masahide (Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine) ,  Fukui Michiaki (Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine)
Material： Journal of Clinical Biochemistry and Nutrition  (JCBN)
Volume： 65  Issue： 1  Page： 23-28(J-STAGE)  Publication year： 2019 
JST Material Number： X0851A  ISSN： 0912-0009  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： mouse(animal) ,...
Semi thesaurus term： db/db mice ,...

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Author keywords (5)： sodium glucose cotransporter-2 inhibitor ,  luseogliflozin ,  muscle atrophy ,  foxo1 ,  sarcopenia

JST classification (1)： Basic research of drugs acting on carbohydrate metabolism  (GW13020Q)

Substance index (1)： Luseogliflozin

Reference (26)：

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• 2 OkamuraT, Miki A, Hashimoto Y, et al. Shortage of energy intake rather than protein intake is associated with sarcopenia in elderly patients with type 2 diabetes: a cross-sectional study of the KAMOGAWA-DM cohort. J Diabetes 2018. DOI: 10.1111/1753-0407.12874.
• 3 Park S, Na W, Sohn C. Relationship between osteosarcopenic obesity and dietary inflammatory index in postmenopausal Korean women: 2009 to 2011 Korea National Health and Nutrition Examination Surveys. J Clin Biochem Nutr 2018; 63: 211-216.
• 4 Kim TN, Park MS, Yang SJ, et al. Prevalence and determinant factors of sarcopenia in patients with type 2 diabetes: the Korean Sarcopenic Obesity Study (KSOS). Diabetes Care 2010; 33: 1497-1499.
• 5 Hashimoto Y, Osaka T, Fukuda T, Tanaka M, Yamazaki M, Fukui M. The relationship between hepatic steatosis and skeletal muscle mass index in men with type 2 diabetes. Endocr J 2016; 63: 877-884.

Terms in the title (10)： ナトリウム ,  グルコース ,  共輸送体 ,  阻害剤 ,  ルセオグリフロジン ,  FoxO1 ,  発現 ,  Db ,  マウス ,  筋萎縮