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J-GLOBAL ID：201902279192911638   Reference number：19A0768072

Immunohistochemistry for Anti-diabetes Drug, Alogliptin Using a Newly Prepared Monoclonal Antibody: Its Precise Localization in Rat Small Intestine

新たに作製したモノクローナル抗体を用いる抗糖尿病薬アログリプチンの免疫組織化学:ラット小腸における正確な局在性

Author (4)： Yamamoto Yuta (Department of Applied Life Science, Faculty of Biotechnology and Life Science, Sojo University) ,  Yamamoto Yutaro (Department of Applied Life Science, Faculty of Biotechnology and Life Science, Sojo University) ,  Saita Tetsuya (Department of Applied Life Science, Faculty of Biotechnology and Life Science, Sojo University) ,  Shin Masashi (Department of Applied Life Science, Faculty of Biotechnology and Life Science, Sojo University)
Material： Acta Histochemica et Cytochemica (Web)  (Acta Histochem Cytochem (Web))
Volume： 52  Issue： 1  Page： 27-34(J-STAGE)  Publication year： 2019 
JST Material Number： U0129A  ISSN： 1347-5800  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： rat ,...
Semi thesaurus term： Chronopharmacokinetics ,...

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Author keywords (5)： alogliptin ,  immunohistochemistry ,  localization ,  intestine ,  rat

JST classification (2)： Basic research of drugs acting on carbohydrate metabolism  (GW13020Q) ,  Intestines  (EJ06040N)

Substance index (1)： alogliptin

Reference (35)：

• 1 Bai, J. P. (1994) Distribution of brush-border membrane peptidases along the rat intestine. Pharm. Res. 11; 897-900.
• 2 Christopher, R., Convingtone, P., Davenport, M., Fleck, P., Mekki, Q. A., Wann, E. R. and Karim, A. (2008) Pharmaco­kinetics, pharmacodynamics, and tolerability of single increasing does of the dipeptidyl peptidase-4 inhibitor alogliptin in healthy male subjects. Clin. Ther. 30; 513-527.
• 3 Clancy, B. and Cauller, L. J. (1998) Reduction of background autofluorescence in brain sections following immersion in sodium borohydride. J. Neurosci. Methods 83; 97-102.
• 4 Drucker, D. J. and Nauck, N. A. (2006) The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 368; 1696-1705.
• 5 Egan, A. G., Blind, E., Dunder, K., de Graeff, P. A., Hummer, B. T., Bourcier, T. and Rosebraugh, C. (2014) Pancreatic safety of incretin-based drugs-FDA and EMA assessment. N. Engl. J. Med. 370; 794-797.

Terms in the title (8)： 作製 ,  モノクローナル抗体 ,  抗糖尿病薬 ,  アログリプチン ,  免疫組織化学 ,  ラット ,  小腸 ,  局在性