Art

J-GLOBAL ID：201902279686744081   Reference number：19A0197256

Development of an anti-hepatitis B virus (HBV) agent through the structure-activity relationship of the interferon-like small compound CDM-3008

インターフェロン様小化合物CDM-3008の構造活性相関による抗B型肝炎ウイルス(HBV)剤の開発【JST・京大機械翻訳】

Author (9)： Takahashi Nobuaki (Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan) ,  Hayashi Kyohei (Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan) ,  Nakagawa Yusuke (Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan) ,  Furutani Yutaka (Liver Cancer Prevention Research Unit, RIKEN Center for Integrative Medical Sciences, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan) ,  Toguchi Mariko (Liver Cancer Prevention Research Unit, RIKEN Center for Integrative Medical Sciences, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan) ,  Shiozaki-Sato Yumi (Liver Cancer Prevention Research Unit, RIKEN Center for Integrative Medical Sciences, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan) ,  Sudoh Masayuki (Liver Cancer Prevention Research Unit, RIKEN Center for Integrative Medical Sciences, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan) ,  Kojima Soichi (Liver Cancer Prevention Research Unit, RIKEN Center for Integrative Medical Sciences, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan) ,  Kakeya Hideaki (Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 27  Issue： 3  Page： 470-478  Publication year： 2019 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Hepatitis B, a viral infectiou...

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Thesaurus term： *Structure-Activity Relationship ,  liver tumor ,  *interferon ,  pharmaceutical preparation ,  *Hepatitis B virus ,  human ,  Mus musculus ,  solubility (property) ,  small molecule ,  *hepatitis B ,  viral disease ,  nucleoside ,  solubility ,  Liver Cirrhosis ,  Half-Life ,  *microorganism ,  *Hepatitis Viruses ,  *Hepadnaviridae ,  Myomorpha

Author keywords (4)： Hepatitis B virus ,  Anti-HBV agent ,  Interferon ,  Structure-activity relationship

JST classification (1)： Basic research of antiviral drugs  (GW17040O)

Terms in the title (5)： インターフェロン ,  構造活性相関 ,  B型肝炎ウイルス ,  HBV ,  開発