Art

J-GLOBAL ID：201902279699789483   Reference number：19A1963346

Tetrandrine and cepharanthine induce apoptosis through caspase cascade regulation, cell cycle arrest, MAPK activation and PI3K/Akt/mTOR signal modification in glucocorticoid resistant human leukemia Jurkat T cells

テトラトランドリンおよびセファランチンはグルココルチコイド耐性ヒト白血病Jurkat T細胞におけるカスパーゼカスケード調節,細胞周期停止,MAPK活性化およびPI3K/Akt/mTORシグナル修飾を介してアポトーシスを誘導する【JST・京大機械翻訳】

Author (12)： Xu Wencheng (Department of Pharmacy, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, PR China) ,  Xu Wencheng (Institute of Traditional Chinese Medicine, Hubei Province Academy of Traditional Chinese Medicine, Wuhan, PR China) ,  Wang Xiaoqin (Institute of Traditional Chinese Medicine, Hubei Province Academy of Traditional Chinese Medicine, Wuhan, PR China) ,  Wang Xiaoqin (Department of Nephrology, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, PR China) ,  Tu Yuanchao (Institute of Traditional Chinese Medicine, Hubei Province Academy of Traditional Chinese Medicine, Wuhan, PR China) ,  Tu Yuanchao (Department of Nephrology, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, PR China) ,  Masaki Hiroshi (Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan) ,  Tanaka Sachiko (Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan) ,  Onda Kenji (Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan) ,  Sugiyama Kentaro (Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan) ,  Yamada Haruki (Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan) ,  Hirano Toshihiko (Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan)
Material： Chemico-Biological Interactions  (Chem Biol Interact)
Volume： 310  Page： Null  Publication year： 2019 
JST Material Number： H0058B  ISSN： 0009-2797  CODEN： CBINA  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Tetrandrine (TET) and cepharan...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=19A1963346&from=J-GLOBAL&jstjournalNo=H0058B") }}

Thesaurus term： Up-Regulation ,  *Leukemia ,  Bax protein ,  p53 protein ,  *Apoptosis ,  NF-kappaB ,  *caspase ,  in vitro experiment ,  Down-Regulation ,  *human ,  time dependence ,  DNA synthetic period ,  BCL-2 ,  *Akt/protein kinase B ,  macrocyclic compound ,  nitrogen heterocyclic compound ,  oxygen heterocyclic compound ,  bridged compound ,  phenol ether ,  polynuclear aromatic compound

Author keywords (5)： Tetrandrine ,  Cepharanthine ,  T cell acute lymphoblastic leukemia ,  Jurkat T cell ,  Apoptosis

JST classification (3)： Cell physiology in general  (EF02010S) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (1)： Cepharanthine

Terms in the title (16)： セファランチン ,  グルココルチコイド耐性 ,  ヒト ,  白血病 ,  T細胞 ,  調節 ,  細胞周期停止 ,  MAPK ,  活性化 ,  PI3K ,  Akt ,  mTOR ,  シグナル ,  修飾 ,  アポトーシス ,  誘導