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J-GLOBAL ID：201902280002312873   Reference number：19A0962788

Roles of Gut-Derived Secretory Factors in the Pathogenesis of Non-Alcoholic Fatty Liver Disease and Their Possible Clinical Applications

非アルコール性脂肪肝疾患の病因における腸由来分泌因子の役割とその臨床応用の可能性【JST・京大機械翻訳】

Author (10)： Okubo Hirofumi (Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan) ,  Kushiyama Akifumi (Division of Diabetes and Metabolism, The Institute for Adult Diseases, Asahi Life Foundation, Tokyo 103-0002, Japan) ,  Nakatsu Yusuke (Department of Medical Chemistry, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8551, Japan) ,  Yamamotoya Takeshi (Department of Medical Chemistry, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8551, Japan) ,  Matsunaga Yasuka (Center for Translational Research in Infection & Inflammation, School of Medicine, Tulane University, 6823 St. Charles Avenue, New Orleans, LA 70118, USA) ,  Fujishiro Midori (Division of Diabetes and Metabolic Diseases, Nihon University School of Medicine, Tokyo 173-8610, Japan) ,  Sakoda Hideyuki (Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, Japan) ,  Ohno Haruya (Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan) ,  Yoneda Masayasu (Department of Preventive Medicine for Diabetes and Lifestyle-related Diseases, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan) ,  Asano Tomoichiro (Department of Medical Chemistry, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8551, Japan)
Material： International Journal of Molecular Sciences (Web)  (Int J Mol Sci (Web))
Volume： 19  Issue： 10  Page： 3064  Publication year： 2018 
JST Material Number： U7038A  ISSN： 1422-0067  CODEN： IJMCFK  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： The rising prevalence of non-a...

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Thesaurus term： hormone ,  Causality ,  therapeutic planning ,  metabolic syndrome ,  human ,  *pathogenesis ,  FGF ,  analogical material ,  Glucagon-Like Peptides ,  *Secretory Component
Semi thesaurus term： 治療標的 ,  臨床評価 ,  非アルコール性脂肪性肝炎 ,  *臨床応用 ,  *非アルコール性脂肪性肝疾患 , 【Automatic Indexing@JST】

Author keywords (8)： non-alcoholic fatty liver disease ,  non-alcoholic steatohepatitis ,  gut-liver axis ,  resistin like molecule β ,  glucagon-like peptide-1 ,  glucagon-like peptide-2 ,  fibroblast growth factor 19 ,  neurotensin

JST classification (3)： Basic medicine on digestive system  (GH01020E) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Digestive system diseases  (GH03000W)

Reference (132)：

• Vernon, G.; Baranova, A.; Younossi, Z.M. Systematic review: The epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment. Pharmacol. Ther. 2011, 34, 274-285.
• Younossi, Z.M.; Stepanova, M.; Afendy, M.; Fang, Y.; Younossi, Y.; Mir, H.; Srishord, M. Changes in the prevalence of the most common causes of chronic liver diseases in the United States from 1988 to 2008. Clin. Gastroenterol. Hepatol. 2011, 9, 524-530.
• Hashimoto, E.; Taniai, M.; Tokushige, K. Characteristics and diagnosis of NAFLD/NASH. J. Gastroenterol. Hepatol. 2013, 28 (Suppl. 4), 64-70.
• Targher, G.; Day, C.P.; Bonora, E. Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N. Engl. J. Med. 2010, 363, 1341-1350.
• Brodosi, L.; Marchignoli, F.; Petroni, M.L.; Marchesini, G. NASH: A glance at the landscape of pharmacological treatment. Ann. Hepatol. 2016, 15, 673-681.

Terms in the title (7)： 非アルコール性脂肪肝疾患 ,  病因 ,  腸 ,  分泌因子 ,  役割 ,  臨床応用 ,  可能性