Art

J-GLOBAL ID：201902280574642453   Reference number：19A2102202

Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity

オレキシン1受容体アンタゴニストYNT-707の必須構造 IV オレキシン1受容体拮抗活性に対する4,5-エポキシモルフィナンにおけるD-環の役割【JST・京大機械翻訳】

Author (15)： Saitoh Tsuyoshi (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Seki Kazunori (Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan) ,  Nakajima Ryo (Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan) ,  Yamamoto Naoshi (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Kutsumura Noriki (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Nagumo Yasuyuki (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Irukayama-Tomobe Yoko (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Ogawa Yasuhiro (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Ishikawa Yukiko (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Tanimura Ryuji (Pharmaceutical Research Laboratories, Toray Industries Inc., 6-10-1 Tebiro, Kamakura, Kanagawa 248-8555, Japan) ,  Yanagisawa Masashi (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Yanagisawa Masashi (R&D Center for Frontiers of Mirai in Policy and Technology (F-MIRAI), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Yanagisawa Masashi (Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA) ,  Nagase Hiroshi (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Nagase Hiroshi (Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 29  Issue： 18  Page： 2655-2658  Publication year： 2019 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The orexin 1 receptor (OX<sub>...

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Thesaurus term： *antagonism ,  *receptor ,  side chain ,  determination factor ,  binding affinity ,  *Orexins ,  nitrogen heterocyclic compound ,  bridged compound ,  morphinan alkaloid ,  polynuclear aromatic compound
Semi thesaurus term： *アンタゴニスト ,  受容体拮抗薬 , 【Automatic Indexing@JST】

Author keywords (5)： Orexin ,  Nalfurafine ,  YNT-707 ,  Ring removal ,  Morphinan

JST classification (1)： Synthesis of drugs  (GV01030F)

Substance index (1)： Morphinan

Terms in the title (7)： オレキシン ,  受容体アンタゴニスト ,  YNT-707 ,  受容体 ,  拮抗活性 ,  環 ,  役割