Art

J-GLOBAL ID：201902280827766555   Reference number：19A2409937

Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2

ホスホエタノールアミン蓄積は,PCYT2のダウンレギュレーションを通してグルタミン飢餓下で癌細胞を保護する【JST・京大機械翻訳】

Author (37)： Osawa Tsuyoshi (Division of Integrative Nutriomics and Oncology, RCAST, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan) ,  Shimamura Teppei (Department of Systems Biology, Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan) ,  Saito Kyoko (Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo 162-8640, Japan) ,  Hasegawa Yoko (Division of Integrative Nutriomics and Oncology, RCAST, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan) ,  Ishii Naoko (Division of Integrative Nutriomics and Oncology, RCAST, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan) ,  Nishida Miyuki (Division of Integrative Nutriomics and Oncology, RCAST, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan) ,  Ando Ritsuko (Division of Integrative Nutriomics and Oncology, RCAST, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan) ,  Kondo Ayano (Division of Genome Science, RCAST, The University of Tokyo, Tokyo 153-8904, Japan) ,  Anwar Muyassar (Division of Genome Science, RCAST, The University of Tokyo, Tokyo 153-8904, Japan) ,  Tsuchida Rika (Division of Integrative Nutriomics and Oncology, RCAST, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan) ,  Hino Shinjiro (Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan) ,  Sakamoto Akihisa (Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan) ,  Igarashi Kaori (Institute for Advanced Biosciences, Keio University, Tsuruoka 997-0052, Japan) ,  Saitoh Kaori (Institute for Advanced Biosciences, Keio University, Tsuruoka 997-0052, Japan) ,  Kato Keiko (Institute for Advanced Biosciences, Keio University, Tsuruoka 997-0052, Japan) ,  Endo Keiko (Institute for Advanced Biosciences, Keio University, Tsuruoka 997-0052, Japan) ,  Yamano Shotaro (Department of Molecular Pathology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan) ,  Kanki Yasuharu (Isotope Science Center, The University of Tokyo, Tokyo 113-0032, Japan) ,  Matsumura Yoshihiro (Division of Metabolic Medicine, RCAST, The University of Tokyo, Tokyo 153-8904, Japan) ,  Minami Takashi (Division of Molecular and Vascular Biology, IRDA, Kumamoto University, Kumamoto 860-0811, Japan) ,  Tanaka Toshiya (Laboratory for Systems Biology and Medicine, RCAST, The University of Tokyo, Tokyo 153-8904, Japan) ,  Anai Motonobu (Laboratory for Systems Biology and Medicine, RCAST, The University of Tokyo, Tokyo 153-8904, Japan) ,  Wada Youichiro (Isotope Science Center, The University of Tokyo, Tokyo 113-0032, Japan) ,  Wanibuchi Hideki (Department of Molecular Pathology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan) ,  Hayashi Mitsuhiro (Division of Clinical Pharmacology and Translational Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan) ,  Hamada Akinobu (Division of Molecular Pharmacology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan) ,  Yoshida Masayuki (Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo 104-0045, Japan) ,  Yachida Shinichi (Department of Cancer Genome Informatics, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan) ,  Nakao Mitsuyoshi (Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan) ,  Sakai Juro (Division of Metabolic Medicine, RCAST, The University of Tokyo, Tokyo 153-8904, Japan) ,  Sakai Juro (Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan) ,  Aburatani Hiroyuki (Division of Genome Science, RCAST, The University of Tokyo, Tokyo 153-8904, Japan) ,  Shibuya Masabumi (Institute of Physiology and Medicine, Jobu University, 634-1 Toyazuka-machi, Isesaki, Gunma 372-8588, Japan) ,  Hanada Kentaro (Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo 162-8640, Japan) ,  Miyano Satoru (Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Soga Tomoyoshi (Institute for Advanced Biosciences, Keio University, Tsuruoka 997-0052, Japan) ,  Kodama Tatsuhiko (Laboratory for Systems Biology and Medicine, RCAST, The University of Tokyo, Tokyo 153-8904, Japan)
Material： Cell Reports
Volume： 29  Issue： 1  Page： 89-103.e7  Publication year： 2019 
JST Material Number： W3124A  ISSN： 2211-1247  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Tolerance to severe tumor micr...

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Thesaurus term： *tumor cell ,  biosynthesis ,  targeting ,  *down-regulation ,  transcription factor ,  human(primates) ,  phosphatidylethanolamine ,  enzyme ,  amino acid ,  aliphatic amine ,  aliphatic carboxylic acid ,  carboxamide ,  dicarboxylic acid ,  primary amine ,  aliphatic alcohol ,  inorganic acid ester ,  aminoalcohol
Semi thesaurus term： 腫瘍進行 ,  予後不良 ,  過剰発現 ,  メタボローム ,  栄養飢餓 , 【Automatic Indexing@JST】

Author keywords (9)： cancer metabolism ,  tumor microenvironments ,  hypoxia ,  nutrient starvation ,  glutamine deprivation ,  amino acids ,  phosphoethanolamine ,  PCYT2 ,  PE biosynthesis

JST classification (3)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Cell physiology in general  (EF02010S) ,  Gene expression  (EC02040Q)

Substance index (2)： Glutamine ,  Phosphoethanolamine

Terms in the title (6)： ホスホエタノールアミン ,  蓄積 ,  ダウンレギュレーション ,  グルタミン ,  飢餓 ,  癌細胞