Art

J-GLOBAL ID：201902281031201259   Reference number：19A2431232

Novel p97/VCP inhibitor induces endoplasmic reticulum stress and apoptosis in both bortezomib-sensitive and -resistant multiple myeloma cells

新規p97/VCP阻害剤は,ボルテゾミブ感受性および耐性多発性骨髄腫細胞の両方で小胞体ストレスおよびアポトーシスを誘導する

Author (16)： Nishimura Nao (Departments of Hematology, Rheumatology, and Infectious Disease, Kumamoto University Graduate School of Medicine, Kumamoto, Japan) ,  Radwan Mohamed O. (Faculty of Life Sciences, Department of Bioorganic Medicinal Chemistry, Kumamoto University, Kumamoto, Japan) ,  Radwan Mohamed O. (Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Cairo, Egypt) ,  Amano Masayuki (Departments of Hematology, Rheumatology, and Infectious Disease, Kumamoto University Graduate School of Medicine, Kumamoto, Japan) ,  Endo Shinya (Departments of Hematology, Rheumatology, and Infectious Disease, Kumamoto University Graduate School of Medicine, Kumamoto, Japan) ,  Fujii Eri (Faculty of Medical Sciences, Division of Informative Clinical Sciences, Kumamoto University, Kumamoto, Japan) ,  Hayashi Hironori (Departments of Hematology, Rheumatology, and Infectious Disease, Kumamoto University Graduate School of Medicine, Kumamoto, Japan) ,  Ueno Shikiko (Departments of Hematology, Rheumatology, and Infectious Disease, Kumamoto University Graduate School of Medicine, Kumamoto, Japan) ,  Ueno Niina (Departments of Hematology, Rheumatology, and Infectious Disease, Kumamoto University Graduate School of Medicine, Kumamoto, Japan) ,  Tatetsu Hiro (Departments of Hematology, Rheumatology, and Infectious Disease, Kumamoto University Graduate School of Medicine, Kumamoto, Japan) ,  Hata Hiroyuki (Faculty of Medical Sciences, Division of Informative Clinical Sciences, Kumamoto University, Kumamoto, Japan) ,  Okamoto Yoshinari (Faculty of Life Sciences, Department of Bioorganic Medicinal Chemistry, Kumamoto University, Kumamoto, Japan) ,  Otsuka Masami (Faculty of Life Sciences, Department of Bioorganic Medicinal Chemistry, Kumamoto University, Kumamoto, Japan) ,  Mitsuya Hiroaki (Departments of Hematology, Rheumatology, and Infectious Disease, Kumamoto University Graduate School of Medicine, Kumamoto, Japan) ,  Matsuoka Masao (Departments of Hematology, Rheumatology, and Infectious Disease, Kumamoto University Graduate School of Medicine, Kumamoto, Japan) ,  Okuno Yutaka (Departments of Hematology, Rheumatology, and Infectious Disease, Kumamoto University Graduate School of Medicine, Kumamoto, Japan)
Material： Cancer Science (Web)  (Cancer Sci (Web))
Volume： 110  Issue： 10  Page： 3275-3287  Publication year： 2019 
JST Material Number： U0505A  ISSN： 1349-7006  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： cultured cell ,...
Semi thesaurus term： cell physiology ,...

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Author keywords (5)： apoptosis ,  ERAD ,  myeloma ,  OSSL_320596 ,  p97/VCP

JST classification (1)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (1)： OSSL-325096

Terms in the title (11)： p97 ,  VCP ,  阻害剤 ,  ボルテゾミブ ,  感受性 ,  耐性 ,  多発性骨髄腫 ,  細胞 ,  小胞体ストレス ,  アポトーシス ,  誘導