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J-GLOBAL ID：201902281171747834   Reference number：19A1480363

Generation of hyperlipidemic rabbit models using multiple sgRNAs targeted CRISPR/Cas9 gene editing system

多重SGRNA標的CRISPR/Cas9遺伝子編集システムを用いた高脂血症ウサギモデルの作成【JST・京大機械翻訳】

Author (17)： Yuan Tingting (Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, China) ,  Zhong Yi (Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, China) ,  Wang Yingge (Affiliated Hospital of Yangzhou University, Yangzhou, China) ,  Zhang Ting (College of Veterinary Medicine, Yangzhou University, Yangzhou, China) ,  Lu Rui (College of Veterinary Medicine, Yangzhou University, Yangzhou, China) ,  Lu Rui (Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses, Yangzhou, China) ,  Zhou Minya (College of Veterinary Medicine, Yangzhou University, Yangzhou, China) ,  Lu Yaoyao (Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, China) ,  Yan Kunning (Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, China) ,  Chen Yajie (Department of Molecular Pathology, Faculty of Medicine, Graduate School of Medical Sciences, University of Yamanashi, Yamanashi, Japan) ,  Hu Zhehui (Beijing hospital, Beijing, China) ,  Liang Jingyan (Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, China) ,  Liang Jingyan (Jiangsu Key laboratory of integrated traditional Chinese and Western Medicine for prevention and treatment of Senile Diseases, Yangzhou University, Yangzhou, China) ,  Liang Jingyan (Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses, Yangzhou, China) ,  Fan Jianglin (Department of Molecular Pathology, Faculty of Medicine, Graduate School of Medical Sciences, University of Yamanashi, Yamanashi, Japan) ,  Cheng Yong (College of Veterinary Medicine, Yangzhou University, Yangzhou, China) ,  Cheng Yong (Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses, Yangzhou, China)
Material： Lipids in Health and Disease (Web)
Volume： 18  Issue： 1  Page： 69  Publication year： 2019 
JST Material Number： U7391A  ISSN： 1476-511X  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： To generate novel rabbit model...

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Thesaurus term： allele ,  Arteriosclerosis ,  wild type ,  Mutation ,  *hyperlipidemia ,  apo E ,  mRNA ,  Western blotting ,  human ,  *gene ,  Atherosclerosis ,  Aorta ,  total cholesterol value ,  sgRNA ,  *Cas9 protein ,  *metabolic disease ,  bioassay
Semi thesaurus term： *Cas9 , 【Automatic Indexing@JST】

Author keywords (5)： CRISPR/Cas9 ,  Hypercholesterolemia ,  Atherosclerosis ,  Rabbits ,  Multiple sgRNAs

JST classification (2)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Metabolism and nutrition of lipids  (EJ02034Q)

Reference (36)：

• Esmaillzadeh, A., Azadbakht,L. Food intake patterns may explain the high prevalence of cardiovascular risk factors among Iranian women. J Nutr, 2008.138(8):1469-1475.
• Mycobiology; Hyperlipidemic inhibitory effects of Phellinus pini in rats fed with a high fat and cholesterol diet; KH Im, J Choi, SA Baek; 46; 2; 2018; 159-167; 10.1080/12298093.2018.1461316; citation_id=CR2
• Sithu SD, Malovichko MV, Riggs KA, et al. Atherogenesis and metabolic dysregulation in LDL receptor-knockout rats. JCI Insight. 2017;2(9).
• FEBS J; Characterization of a hypertriglyceridemic transgenic miniature pig model expressing human apolipoprotein CIII; J Wei, H Ouyang, Y Wang; 279; 1; 2012; 91-99; 10.1111/j.1742-4658.2011.08401.x; citation_id=CR4
• Oncotarget; CRISPR/Cas9-mediated ApoE-/- and LDLR-/- double gene knockout in pigs elevates serum LDL-C and TC levels; L Huang, ZD Hua, HW Xiao; 8; 23; 2017; 37751-37760; citation_id=CR5

Terms in the title (8)： 多重 ,  sgRNA ,  標的 ,  CRISPR ,  Cas9 ,  遺伝子編集 ,  高脂血症 ,  ウサギモデル