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J-GLOBAL ID：201902281204370847   Reference number：19A0604337

Optimization of the treatment conditions with glycogen synthase kinase-3 inhibitor towards enhancing the proliferation of human induced pluripotent stem cells while maintaining an undifferentiated state under feeder-free conditions

フィーダーフリー条件下で未分化状態を維持しながらヒトiPS細胞の増殖を促進するためのグリコーゲン合成酵素キナーゼ-3阻害剤による処理条件の最適化

Author (3)： Yoda Kiyomi (Faculty of Life and Environmental Sciences, Graduate Faculty of Interdisciplinary Research, University of Yamanashi, 4-4-37 Takeda, Kofu, Yamanashi 400-8510, Japan) ,  Ohnuki Yoshitsugu (Faculty of Life and Environmental Sciences, Graduate Faculty of Interdisciplinary Research, University of Yamanashi, 4-4-37 Takeda, Kofu, Yamanashi 400-8510, Japan) ,  Kurosawa Hiroshi (Faculty of Life and Environmental Sciences, Graduate Faculty of Interdisciplinary Research, University of Yamanashi, 4-4-37 Takeda, Kofu, Yamanashi 400-8510, Japan)
Material： Journal of Bioscience and Bioengineering
Volume： 127  Issue： 3  Page： 381-387  Publication year： Mar. 2019 
JST Material Number： G0535B  ISSN： 1389-1723  CODEN： JBBIF6  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *molecular targeting drug ,...
Semi thesaurus term： small molecule inhibitor

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Author keywords (5)： Cell proliferation ,  CHIR99021 ,  Human induced pluripotent stem cells ,  Undifferentiated state ,  Differentiation

JST classification (2)： Influence on animals  (EE05040R) ,  Cell physiology in general  (EF02010S)

Substance index (1)： CT-99021

Reference (24)：

• Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichikawa, T., Tomoda, K., and Yamanaka, S.: Induction of pluripotent stem cells from adult human fibroblasts by defined factors, Cell, 131, 861-871 (2007).
• Thomson, J. A., Itskovitz-Eldor, J., Shapiro, S. S., Waknitz, M. A., Swiergiel, J. J., Marshall, V. S., and Jones, J. M.: Embryonic stem cell lines derived from human blastocysts, Science, 282, 1145-1147 (1998).
• Sato, N., Meijer, L., Skaltsounis, L., Greengard, P., and Brivanlou, A. H.: Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor, Nat. Med., 10, 55-63 (2004).
• Borowiak, M., Maehr, R., Chen, S., Chen, A. E., Tang, W., Fox, J. L., Schreiber, S. L., and Melton, D. A.: Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells, Cell Stem Cell, 4, 348-358 (2009).
• Zhu, S., Wurdak, H., Wang, J., Lyssiotis, C. A., Peters, E. C., Cho, C. Y., Wu, X., and Schultz, P. G.: A small molecule primes embryonic stem cells for differentiation, Cell Stem Cell, 4, 416-426 (2009).

Terms in the title (9)： フィーダー ,  分化 ,  ヒトiPS細胞 ,  増殖 ,  促進 ,  グリコーゲン合成酵素キナーゼ ,  阻害剤 ,  処理条件 ,  最適化