Art

J-GLOBAL ID：201902281549367619   Reference number：19A2365705

Superior Penetration and Cytotoxicity of HPMA Copolymer Conjugates of Pirarubicin in Tumor Cell Spheroid

腫瘍細胞スフェロイドにおけるピラルビシンのHPMA共重合体複合体の優れた浸透と細胞毒性【JST・京大機械翻訳】

Author (7)： Nakamura Hideaki (Faculty of Pharmaceutical Sciences, Sojo University, Japan) ,  Koziolova Eva (Institute of Macromolecular Chemistry, Czech Academy of Sciences, Czech Republic) ,  Chytil Petr (Institute of Macromolecular Chemistry, Czech Academy of Sciences, Czech Republic) ,  Etrych Tomas (Institute of Macromolecular Chemistry, Czech Academy of Sciences, Czech Republic) ,  Haratake Mamoru (Faculty of Pharmaceutical Sciences, Sojo University, Japan) ,  Maeda Hiroshi (Department of Microbiology, Kumamoto University School of Medical Sciences, Japan) ,  Maeda Hiroshi (BioDynamics Research Foundation, Japan)
Material： Molecular Pharmaceutics
Volume： 16  Issue： 8  Page： 3452-3459  Publication year： 2019 
JST Material Number： W3686A  ISSN： 1543-8384  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： N-(2-Hydroxypropyl)-methacryla...

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Thesaurus term： antitumor action ,  *tumor ,  in vitro experiment ,  antitumor drug ,  effect ,  *cytotoxicity ,  monolayer ,  *tumor cell ,  *complex (substance) ,  solid tumor ,  *Osmosis ,  *Cellular Spheroids ,  acetal ,  amino sugar ,  quinone ,  glycoside (except carbohydrate) ,  cyclic ether ,  polyphenol ,  deoxysugar ,  pyranoside ,  phenol ether ,  polynuclear aromatic compound ,  hydroxy ketone ,  polyol
Semi thesaurus term： *スフェロイド , 【Automatic Indexing@JST】

Author keywords (5)： pirarubicin (THP) ,  tumor spheroid cell ,  HPMA polymer ,  penetration ,  drug delivery

JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Experimental treatment for tumors  (GE02040Y)

Substance index (1)： Pirarubicin

Terms in the title (8)： 腫瘍 ,  細胞スフェロイド ,  ピラルビシン ,  HPMA ,  共重合体 ,  複合体 ,  浸透 ,  細胞毒性