Art

J-GLOBAL ID：201902281728787335   Reference number：19A0883074

Improved Intranasal Retentivity and Transnasal Absorption Enhancement by PEGylated Poly-l-ornithine

PEG化ポリ-L-オルニチンによる経鼻吸収および経鼻吸収増強の改善【JST・京大機械翻訳】

Author (8)： Kamiya Yusuke (Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan) ,  Yamaki Tsutomu (Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan) ,  Omori Shigehiro (Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan) ,  Uchida Masaki (Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan) ,  Ohtake Kazuo (Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan) ,  Kimura Mitsutoshi (Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan) ,  Yamazaki Hiroshi (Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, 3-3165 Higashi-tamagawa Gakuen, Machida, Tokyo 194-8543, Japan) ,  Natsume Hideshi (Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan)
Material： Pharmaceuticals (Web)
Volume： 11  Issue： 1  Page： 9  Publication year： 2018 
JST Material Number： U7257A  ISSN： 1424-8247  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： We reported that the introduct...

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Thesaurus term： coefficient of viscosity ,  open system ,  absorption promoter ,  retention time ,  in vitro experiment ,  plasma concentration ,  closed loop system ,  Rattus ,  administration (biology) ,  intranasal administration ,  *Plasma ,  *polyethylene glycolylation ,  *nasal absorption ,  coefficient ,  transport coefficient ,  degree ,  Myomorpha
Semi thesaurus term： 機能性 ,  鼻腔内 , 【Automatic Indexing@JST】

Author keywords (5)： poly-<span style=”font-variant: small-caps;”>l-ornithine (PLO) ,  polyethylene glycol (PEG) ,  absorption enhancer ,  intranasal administration ,  retentivity

JST classification (1)： Cell physiology in general  (EF02010S)

Reference (26)：

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• Natsume, H.; Iwata, S.; Ohtake, K.; Miyamoto, M.; Yamaguchi, M.; Hosoya, K.; Kobayashi, D.; Sugibayashi, K.; Morimoto, Y. Screening of cationic compounds as an absorption enhancer for nasal drug delivery. Int. J. Pharm. 1999, 185, 1-12.
• Natsume, H.; Hori, S.; Tsukune, T.; Iwata, S.; Miyamoto, M.; Sugibayashi, K.; Morimoto, Y.; Yamaguchi, M. Improvement of pharmacological response after intranasal administration of peptide drugs by poly-l-arginine as a novel absorption enhancer in rats. Drug Deliv. Syst. 1999, 14, 21-25.

Terms in the title (4)： PEG化 ,  L-オルニチン ,  経鼻吸収 ,  増強