Art

J-GLOBAL ID：201902283100711815   Reference number：19A1562974

Pazopanib interacts with irinotecan by inhibiting UGT1A1-mediated glucuronidation, but not OATP1B1-mediated hepatic uptake, of an active metabolite SN-38

パゾパニブは活性代謝物SN-38のUGT1A1仲介グルクロン酸化を阻害するが,OATP1B1介在性肝取り込みを阻害することによりイリノテカンと相互作用する【JST・京大機械翻訳】

Author (9)： Iwase Mariko (Department of Pharmacology, Showa University School of Medicine, Tokyo, Japan) ,  Fujita Ken-ichi (Institute of Molecular Oncology, Showa University, Tokyo, Japan) ,  Fujita Ken-ichi (Division of Cancer Cell Biology, Department of Pharmaceutical Science, Showa University School of Pharmacy, Tokyo, Japan) ,  Nishimura Yuki (Department of Pharmacology, Showa University School of Medicine, Tokyo, Japan) ,  Seba Natsumi (Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan) ,  Masuo Yusuke (Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan) ,  Ishida Hiroo (Division of Medical Oncology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan) ,  Kato Yukio (Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan) ,  Kiuchi Yuji (Department of Pharmacology, Showa University School of Medicine, Tokyo, Japan)
Material： Cancer Chemotherapy and Pharmacology
Volume： 83  Issue： 5  Page： 993-998  Publication year： 2019 
JST Material Number： W4134A  ISSN： 1432-0843  Document type： Article
Article type： 短報  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： Pazopanib is an orally active,...

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Thesaurus term： rate theory ,  pharmacokinetics ,  drug interaction ,  UDP glucuronosyltransferase ,  concentration dependence ,  phase (topology) ,  *glucuronic acid conjugation ,  HEK293 cell ,  human ,  plasma concentration ,  metabolite ,  coadministration ,  lactam ,  lactone ,  carbamate ,  hydroxy compound ,  polynuclear aromatic compound ,  phenolic compound ,  molecular targeting drug

Author keywords (5)： Pazopanib ,  UGT1A1 ,  SN-38 ,  Pharmacokinetics ,  Drug-drug interaction

JST classification (1)： Enzyme in general  (EB09010D)

Substance index (3)： Irinotecan ,  SN-38 ,  Pazopanib

Terms in the title (11)： パゾパニブ ,  活性代謝物 ,  SN-38 ,  UGT1A1 ,  仲介 ,  グルクロン酸化 ,  阻害 ,  OATP1B1 ,  取り込み ,  イリノテカン ,  相互作用