Art

J-GLOBAL ID：201902283523546454   Reference number：19A1662127

Population Pharmacokinetics and Pharmacodynamics of Apixaban Linking Its Plasma Concentration to Intrinsic Activated Coagulation Factor X Activity in Japanese Patients with Atrial Fibrillation

心房細動の日本人患者における内因性活性化凝固因子X活性への血漿濃度を結合するアピキサバンの集団薬物動態と薬力学【JST・京大機械翻訳】

Author (14)： Ueshima Satoshi (College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan) ,  Hira Daiki (College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan) ,  Hira Daiki (Department of Pharmacy, Shiga University of Medical Science Hospital, Otsu, Shiga, Japan) ,  Tomitsuka Chiho (College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan) ,  Nomura Miki (College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan) ,  Kimura Yuuma (College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan) ,  Yamane Takuya (College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan) ,  Tabuchi Yohei (Department of Pharmacy, Shiga University of Medical Science Hospital, Otsu, Shiga, Japan) ,  Ozawa Tomoya (Department of Cardiovascular Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan) ,  Itoh Hideki (Department of Cardiovascular Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan) ,  Horie Minoru (Department of Cardiovascular Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan) ,  Horie Minoru (Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Shiga, Japan) ,  Terada Tomohiro (Department of Pharmacy, Shiga University of Medical Science Hospital, Otsu, Shiga, Japan) ,  Katsura Toshiya (College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan)
Material： AAPS Journal
Volume： 21  Issue： 5  Page： 1-9  Publication year： 2019 
JST Material Number： W3977A  ISSN： 1550-7416  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： Apixaban is used in the preven...

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Thesaurus term： cerebral infarction ,  cardiac insufficiency ,  population(statistics) ,  *auricular fibrillation ,  *plasma concentration ,  effectiveness ,  cerebral apoplexy ,  *human(primates) ,  *pharmacodynamics ,  *pharmacokinetics ,  effect
Semi thesaurus term： 共変量 ,  非弁膜症性心房細動 ,  *内因性 ,  *日本人 , 【Automatic Indexing@JST】

Author keywords (4)： apixaban ,  cerebral infarction ,  heart failure ,  population pharmacokinetics and pharmacodynamics

JST classification (2)： Clinical application of drugs acting on blood and body fluid  (GW14020X) ,  Drug therapy(=pharmacotherapy)for cardiovascular system diseases  (GJ05020M)

Substance index (1)： Apixaban

Terms in the title (12)： 心房細動 ,  日本人 ,  患者 ,  内因性 ,  活性化 ,  凝固因子 ,  活性 ,  血漿濃度 ,  アピキサバン ,  集団 ,  薬物動態 ,  薬力学