Art

J-GLOBAL ID：201902283785365280   Reference number：19A0152879

COMPUTATIONAL STUDY FOR THE SELECTIVE AROMATIC NUCLEOPHILIC SUBSTITUTION ON 4-DIMETHYLAMINO-2-METHOXY-3-TRIFLUOROACETYLQUINOLINE

4-ジメチルアミノ-2-メトキシ-3-トリフルオロアセチルキノリン上での選択的芳香族求核置換の計算研究

Author (4)： OTA Norio (Kobe Univ., Kobe, JPN) ,  SASAKAWA Shota (Kobe Univ., Kobe, JPN) ,  KAMITORI Yasuhiro (Kobe Univ., Kobe, JPN) ,  OKADA Etsuji (Kobe Univ., Kobe, JPN)
Material： Heterocycles  (International Journal for Reviews and Communications in Heterocyclic Chemistry)
Volume： 97  Issue： 1  Page： 451-458  Publication year： Sep. 01, 2018 
JST Material Number： S0966A  ISSN： 0385-5414  CODEN： HTCYAM  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： nitrogen heterocyclic compound ,  polynuclear aromatic compound ,  *nucleophilic substitution reaction ,  density functional method ,  process ,  LUMO ,  anion ,  complex (compound) ,  reaction intermediate ,  Meisenheimer complex ,  reaction process ,  *Quinolines ,  *nucleophilic aromatic substitution
Semi thesaurus term： DFT calculation ,  *quinoline derivative ,  *nucleophilic aromatic substitution reaction

JST classification (2)： Substitution reaction  (CF02020B) ,  Quinolines,isoquinolines  (CF07096H)

Substance index (1)： 2-Methoxy-3-(trifluoroacetyl)-4-(dimethylamino)quinoline

Reference (12)：

• R. Filler and Y. Kobayashi, ‘Biomedicinal Aspects of Fluorine Chemistry’, Kodansha & Elsevier Biomedical, Tokyo, 1982.
• R. Filler, ‘Organofluorine Chemicals and Their Industrial Applications’, ed. by R. E. Banks, Ellis Horwood, London, 1979.
• J. T. Welch, Tetrahedron, 1987, 43, 3123.
• R. Filler, Y. Kobayashi, and L. M. Yagupolskii, ‘Organofluorine Compounds in Medicinal Chemistry and Biomedical Applications’, Elsevier, Amsterdam, 1993.
• M. Hatakenaka, S. Adachi, and E. Okada, Heterocycles, 2016, 92, 936.

Terms in the title (3)： 芳香族求核置換 ,  計算 ,  研究