Art

J-GLOBAL ID：201902284173617352   Reference number：19A2655967

Targeting the Janus Kinase Family in Autoimmune Skin Diseases

自己免疫性皮膚疾患におけるJanusキナーゼファミリーの標的化【JST・京大機械翻訳】

Author (3)： Howell Michael D. (Incyte Corporation, Wilmington, DE, United States) ,  Kuo Fiona I. (Incyte Corporation, Wilmington, DE, United States) ,  Smith Paul A. (Incyte Corporation, Wilmington, DE, United States)
Material： Frontiers in Immunology (Web)
Volume： 10  Page： 2342  Publication year： 2019 
JST Material Number： U7074A  ISSN： 1664-3224  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Autoimmune skin diseases are c...

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Thesaurus term： atopic dermatitis ,  *skin disease ,  oral administration ,  *autoimmunity ,  effectiveness ,  STAT transcription factor ,  human(primates) ,  antagonism ,  psoriasis ,  dermatology ,  *targeting ,  therapy
Semi thesaurus term： JAK阻害剤 ,  阻害剤 ,  *Janusキナーゼ , 【Automatic Indexing@JST】

Author keywords (5)： Janus kinase ,  cytokines ,  skin barrier ,  dermatology ,  autoimmunity

JST classification (2)： Immunologic diseases,allergic diseases in general.  (GD04010C) ,  Immunological reaction in general  (ED03010T)

Reference (151)：

• Villarino AV, Kanno Y, O'shea JJ. Mechanisms and consequences of Jak-STAT signaling in the immune system. Nat Immunol. (2017) 18:374-84. doi: 10.1038/ni.3691
• Rawlings JS, Rosler KM, Harrison DA. The JAK/STAT signaling pathway. J Cell Sci. (2004) 117:1281-3. doi: 10.1242/jcs.00963
• Howell MD, Fitzsimons C, Smith PA. JAK/STAT inhibitors and other small molecule cytokine antagonists for the treatment of allergic disease. Ann Allergy Asthma Immunol. (2018) 120:367-75. doi: 10.1016/j.anai.2018.02.012
• Stark GR, Cheon H, Wang Y. Responses to cytokines and interferons that depend upon JAKs and STATs. Cold Spring Harb Perspect Biol. (2018) 10:a028555. doi: 10.1101/cshperspect.a028555
• Maldonado RA, Soriano MA, Perdomo LC, Sigrist K, Irvine DJ, Decker T, et al. Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse. J Exp Med. (2009) 206:877-92. doi: 10.1084/jem.20082900

Terms in the title (5)： 自己免疫 ,  皮膚疾患 ,  Janusキナーゼ ,  ファミリー ,  標的化