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J-GLOBAL ID：201902284291300890   Reference number：19A0376972

Synthesis and Preliminary Evaluation of ¹¹C-Labeled VU0467485/AZ13713945 and Its Analogues for Imaging Muscarinic Acetylcholine Receptor Subtype 4

ムスカリン性アセチルコリン受容体サブタイプ4をイメージングするための11C標識VU0467485/AZ13713945とその類似体の合成と予備評価【JST・京大機械翻訳】

Author (18)： Deng Xiaoyun (Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA) ,  Hatori Akiko (Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan) ,  Chen Zhen (Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA) ,  Kumata Katsushi (Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan) ,  Shao Tuo (Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA) ,  Zhang Xiaofei (Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA) ,  Yamasaki Tomoteru (Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan) ,  Hu Kuan (Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan) ,  Yu Qingzhen (Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA) ,  Ma Longle (Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA) ,  Wang Gangqiang (Hubei Collaborative Innovation Centre for Non-power Nuclear Technology, College of Nuclear Technology & Chemistry and Biology, Hubei University of Science and Technology, Xianning, China) ,  Wang Lu (Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA) ,  Wang Lu (Department of Nuclear Medicine and PET/CT-MRI Center, the First Affiliated Hospital of Jinan University & Institute of Molecular and Functional Imaging, Jinan University, Guangzhou, 510630, China) ,  Shao Yihan (Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK, 73019, USA) ,  Josephson Lee (Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA) ,  Sun Shaofa (Hubei Collaborative Innovation Centre for Non-power Nuclear Technology, College of Nuclear Technology & Chemistry and Biology, Hubei University of Science and Technology, Xianning, China) ,  Zhang Ming-Rong (Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan) ,  Liang Steven (Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA)
Material： ChemMedChem
Volume： 14  Issue： 3  Page： 303-309  Publication year： 2019 
JST Material Number： W1573A  ISSN： 1860-7179  CODEN： CHEMGX  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Muscarinic acetylcholine recep...

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Thesaurus term： Autoradiography ,  optimization ,  *muscarinic receptor ,  purity ,  subunit ,  in vitro experiment ,  PET (tomography) ,  schizophrenia ,  *image processing ,  Radiochemistry ,  Alzheimer Disease ,  attenuation correction ,  Allosteric Site ,  Technology ,  X ray diagnosis ,  Diagnosis ,  image technology ,  Diagnostic Imaging ,  modification
Semi thesaurus term： アゴニスト ,  *サブタイプ , 【Automatic Indexing@JST】

Author keywords (5)： carbon-11 ,  muscarinic acetylcholine receptor subtype 4 ,  positive allosteric modulator ,  positron emission tomography ,  VU0467485/AZ13713945

JST classification (2)： Receptors on cell membrane  (EF04030C) ,  Drugs acting on central nervous system in general  (GW03010A)

Terms in the title (6)： ムスカリン性アセチルコリン受容体 ,  サブタイプ ,  イメージング ,  標識 ,  類似体 ,  評価