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J-GLOBAL ID：201902284449919923   Reference number：19A2693651

Structural Mechanisms Underlying Activity Changes in an AMPA-type Glutamate Receptor Induced by Substitutions in Its Ligand-Binding Domain

リガンド結合ドメインの置換により誘導されるAMPA型グルタミン酸受容体における活性変化の基礎となる構造機構【JST・京大機械翻訳】

Author (9)： Sakakura Masayoshi (Graduate School of Medical Life Science, Yokohama City University, Yokohama 230-0045, Japan) ,  Ohkubo Yumi (Graduate School of Medical Life Science, Yokohama City University, Yokohama 230-0045, Japan) ,  Oshima Hiraku (Laboratory for Biomolecular Function Simulation, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan) ,  Re Suyong (Laboratory for Biomolecular Function Simulation, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan) ,  Ito Masahiro (Graduate School of Medical Life Science, Yokohama City University, Yokohama 230-0045, Japan) ,  Sugita Yuji (Laboratory for Biomolecular Function Simulation, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan) ,  Sugita Yuji (Theoretical Molecular Science Laboratory, RIKEN Cluster for Pioneering Research, Wako 351-0198, Japan) ,  Sugita Yuji (Computational Biophysics Research Team, RIKEN Center for Computational Science, Kobe 650-0047, Japan) ,  Takahashi Hideo (Graduate School of Medical Life Science, Yokohama City University, Yokohama 230-0045, Japan)
Material： Structure
Volume： 27  Issue： 11  Page： 1698-1709.e5  Publication year： 2019 
JST Material Number： A1212A  ISSN： 0969-2126  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： α-Amino-3-hydroxy-5-methyl-4-i...

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Thesaurus term： wild type ,  *receptor ,  rate theory ,  chemical shift ,  crystal structure ,  *glutamate receptor ,  opening ,  desensitization (immunology) ,  steric conformation ,  NMR ,  electric current ,  channel ,  *ligand binding domain ,  amino acid ,  aliphatic amine ,  aliphatic carboxylic acid ,  dicarboxylic acid ,  primary amine
Semi thesaurus term： アゴニスト , 【Automatic Indexing@JST】

Author keywords (6)： AMPAR ,  partial agonism ,  nuclear magnetic resonance (NMR) ,  relaxation dispersion ,  hydrogen-deuterium exchange ,  chemical shift projection analysis (CHESPA)

JST classification (2)： Biological function  (EB03040U) ,  Cell physiology in general  (EF02010S)

Substance index (1)： Glutamic acid

Terms in the title (7)： リガンド結合ドメイン ,  置換 ,  誘導 ,  AMPA ,  グルタミン酸受容体 ,  活性 ,  基礎