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J-GLOBAL ID：201902286024141378   Reference number：19A2656108

Breast Milk-Derived Extracellular Vesicles Enriched in Exosomes From Mothers With Type 1 Diabetes Contain Aberrant Levels of microRNAs

1型糖尿病の母親からのエキソソームに富む母乳由来細胞外小胞はマイクロRNAの異常なレベルを含む【JST・京大機械翻訳】

Author (20)： Mirza Aashiq H. (Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark) ,  Mirza Aashiq H. (Department of Pediatrics E, Copenhagen Diabetes Research Center (CPH-DIRECT), Herlev and Gentofte Hospital, Herlev, Denmark) ,  Kaur Simranjeet (Department of Pediatrics E, Copenhagen Diabetes Research Center (CPH-DIRECT), Herlev and Gentofte Hospital, Herlev, Denmark) ,  Kaur Simranjeet (Steno Diabetes Center Copenhagen, Gentofte, Denmark) ,  Nielsen Lotte B. (Department of Pediatrics E, Copenhagen Diabetes Research Center (CPH-DIRECT), Herlev and Gentofte Hospital, Herlev, Denmark) ,  Storling Joachim (Department of Pediatrics E, Copenhagen Diabetes Research Center (CPH-DIRECT), Herlev and Gentofte Hospital, Herlev, Denmark) ,  Storling Joachim (Steno Diabetes Center Copenhagen, Gentofte, Denmark) ,  Yarani Reza (Steno Diabetes Center Copenhagen, Gentofte, Denmark) ,  Roursgaard Martin (Faculty of Health Sciences, Institute of Public Health, CSS, University of Copenhagen, Copenhagen, Denmark) ,  Mathiesen Elisabeth R. (Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark) ,  Mathiesen Elisabeth R. (Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark) ,  Damm Peter (Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark) ,  Damm Peter (Center for Pregnant Women With Diabetes, Rigshospitalet, Copenhagen, Denmark) ,  Damm Peter (Department of Obstetrics, Rigshospitalet, Copenhagen, Denmark) ,  Svare Jens (Department of Obstetrics, Herlev Hospital, Herlev, Denmark) ,  Mortensen Henrik B. (Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark) ,  Mortensen Henrik B. (Department of Pediatrics E, Copenhagen Diabetes Research Center (CPH-DIRECT), Herlev and Gentofte Hospital, Herlev, Denmark) ,  Pociot Flemming (Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark) ,  Pociot Flemming (Department of Pediatrics E, Copenhagen Diabetes Research Center (CPH-DIRECT), Herlev and Gentofte Hospital, Herlev, Denmark) ,  Pociot Flemming (Steno Diabetes Center Copenhagen, Gentofte, Denmark)
Material： Frontiers in Immunology (Web)
Volume： 10  Page： 2543  Publication year： 2019 
JST Material Number： U7074A  ISSN： 1664-3224  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： The breast milk plays a crucia...

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Thesaurus term： *mother's milk ,  *type 1 diabetes mellitus ,  breast-feeding ,  TNF alpha ,  up-regulation ,  mucosal immunity ,  infant ,  enteric microbe ,  lipopolysaccharide
Semi thesaurus term： 低分子RNA ,  健康 ,  免疫系 ,  発症 ,  *マイクロRNA ,  *エキソソーム , 【Automatic Indexing@JST】

Author keywords (5)： breast milk ,  exosomes ,  miRNAs ,  Type 1 diabetes ,  exomiRs

JST classification (2)： Gene expression  (EC02040Q) ,  Immunological reaction in general  (ED03010T)

Reference (44)：

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• Zhou Q, Li M, Wang X, Li Q, Wang T, Zhu Q, et al. Immune-related microRNAs are abundant in breast milk exosomes. Int J Biol Sci. (2012) 8:118-23. doi: 10.7150/ijbs.8.118
• Liao Y, Du X, Li J, Lönnerdal B. Human milk exosomes and their microRNAs survive digestion in vitro and are taken up by human intestinal cells. Mol Nutr Food Res. (2017) 61:1700082. doi: 10.1002/mnfr.201700082
• Alsaweed M, Hartmann PE, Geddes DT, Kakulas F. MicroRNAs in Breastmilk and the lactating breast: potential immunoprotectors and developmental regulators for the infant and the mother. Int J Environ Res Public Health. (2015) 12:13981-4020. doi: 10.3390/ijerph121113981

Terms in the title (6)： 1型糖尿病 ,  母親 ,  エキソソーム ,  母乳 ,  細胞外小胞 ,  マイクロRNA