Art

J-GLOBAL ID：201902286605911427   Reference number：19A1924110

Fundamental Study of Behaviors of In-Source Collision Induced Dissociation and Shifting the Linear Range of Calibration Curves of Various Drugs and the Metabolites Used for Therapeutic Drug Monitoring

治療薬モニタリングに用いられる種々の薬物と代謝物の較正曲線の線形範囲をシフトさせるインソース衝突誘起解離の挙動の基礎的研究

Author (12)： MAEKAWA Masamitsu (Department of Pharmaceutical Sciences, Tohoku University Hospital) ,  TSUKAMOTO Taku (Shimadzu Corporation) ,  TAKASAKI Shinya (Department of Pharmaceutical Sciences, Tohoku University Hospital) ,  KIKUCHI Masafumi (Department of Pharmaceutical Sciences, Tohoku University Hospital) ,  KIKUCHI Masafumi (Graduate school of Pharmaceutical Sciences, Tohoku University) ,  SATO Yu (Department of Pharmaceutical Sciences, Tohoku University Hospital) ,  OGURA Jiro (Department of Pharmaceutical Sciences, Tohoku University Hospital) ,  HAYAKAWA Yoshihiro (Shimadzu Corporation) ,  YAMAGUCHI Hiroaki (Department of Pharmaceutical Sciences, Tohoku University Hospital) ,  YAMAGUCHI Hiroaki (Graduate school of Pharmaceutical Sciences, Tohoku University) ,  MANO Nariyasu (Department of Pharmaceutical Sciences, Tohoku University Hospital) ,  MANO Nariyasu (Graduate school of Pharmaceutical Sciences, Tohoku University)
Material： Chromatography  (Journal of Separation and Detection Sciences)
Volume： 40  Issue： 2  Page： 71-78(J-STAGE)  Publication year： 2019 
JST Material Number： L1501A  ISSN： 1342-8284  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *therapeutic drug monitoring ,...
Semi thesaurus term： *LC-MS/MS analysis ,...

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Author keywords (5)： LC-MS/MS ,  In-source CID ,  TDM ,  Combination therapy ,  Calibration curve

JST classification (2)： Analysis of drugs  (GV01040Q) ,  Miscellaneous analytical methods of organic compounds  (CC08034J)

Substance index (13)： Axitinib ,  Itraconazol ,  Imatinib ,  Cibenzoline ,  Sunitinib ,  Sorafenib ,  Pazopanib ,  Hydroxyitraconazol ,  Pilzicainide ,  Voriconazole ,  Mycophenolic Acid ,  N-Desethylsunitinib ,  Sorafenib N-oxide

Reference (22)：

• [1] Vesell, E. S.; Passananti, G. T. Clin. Chem. 1971, 17, 851-866.
• [2] Dvorchik, B. H.; Vesell, E. S. Clin. Chem. 1976, 22, 868-878.
• [3] Kahan, B. D.; Keown, P.; Levy, G. A.; Johnson, A. Clin. Therapeut. 2002, 24, 330-350.
• [4] Roberts, J. A.; Norris, R.; Paterson, D. L.; Martin, J. H. Br. J. Clin. Pharmacol. 2011, 73, 27-36.
• [5] Campbell, T. J.; Williams, K. M. Br. J. Clin. Pharmacol. 1998, 46, 307-319.

Terms in the title (12)： 治療薬 ,  モニタリング ,  薬物 ,  代謝物 ,  較正曲線 ,  線形 ,  シフト ,  ソース ,  衝突誘起解離 ,  挙動 ,  基礎 ,  研究