Art

J-GLOBAL ID：201902287180244739   Reference number：19A0791613

Establishment of a rapid and footprint-free protocol for differentiation of human embryonic stem cells into pancreatic endocrine cells with synthetic mRNAs encoding transcription factors

転写因子をコードする合成mRNAによるヒト胚幹細胞の膵臓内分泌細胞への分化のための迅速でフットプリントのないプロトコルの確立【JST・京大機械翻訳】

Author (13)： Ida Hideomi (Department of Systems Medicine, Keio University School of Medicine, Tokyo, Japan) ,  Ida Hideomi (Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Akiyama Tomohiko (Department of Systems Medicine, Keio University School of Medicine, Tokyo, Japan) ,  Ishiguro Keiichiro (Department of Systems Medicine, Keio University School of Medicine, Tokyo, Japan) ,  Goparaju Sravan K. (Department of Systems Medicine, Keio University School of Medicine, Tokyo, Japan) ,  Nakatake Yuhki (Department of Systems Medicine, Keio University School of Medicine, Tokyo, Japan) ,  Chikazawa-Nohtomi Nana (Department of Systems Medicine, Keio University School of Medicine, Tokyo, Japan) ,  Sato Saeko (Department of Systems Medicine, Keio University School of Medicine, Tokyo, Japan) ,  Kimura Hiromi (Department of Systems Medicine, Keio University School of Medicine, Tokyo, Japan) ,  Yokoyama Yukihiro (Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Nagino Masato (Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Ko Minoru S. H. (Department of Systems Medicine, Keio University School of Medicine, Tokyo, Japan) ,  Ko Shigeru B. H. (Department of Systems Medicine, Keio University School of Medicine, Tokyo, Japan)
Material： Stem Cell Research & Therapy (Web)
Volume： 9  Issue： 1  Page： 277  Publication year： 2018 
JST Material Number： U7397A  ISSN： 1757-6512  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Transplantation of pancreatic ...

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Thesaurus term： in vitro experiment ,  *internal secretion ,  insulin ,  *mRNA ,  Transfection ,  versatility ,  *differentiation (biology) ,  siRNA ,  Diabetes Mellitus ,  immunohistochemistry ,  gene ,  DNA ,  *human ,  *transcription factor ,  PDX-1 ,  hypoglycemic drug ,  metabolic drug ,  carbohydrate metabolic drug ,  drug

Author keywords (8)： Embryonic stem cells ,  Endocrine differentiation ,  Transcription factors ,  Synthetic mRNAs ,  Pancreatic β cells ,  PDX1 ,  NKX6.1 ,  siPOU5F1

JST classification (1)： Cell physiology in general  (EF02010S)

Reference (20)：

• Cell; Generation of functional human pancreatic beta cells in vitro; FW Pagliuca, JR Millman, M Gurtler, M Segel, A Van Dervort, JH Ryu, QP Peterson, D Greiner, DA Melton; 159; 2; 2014; 428-439; 10.1016/j.cell.2014.09.040; citation_id=CR1
• Nat Biotechnol; Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells; KA D'Amour, AG Bang, S Eliazer, OG Kelly, AD Agulnick, NG Smart, MA Moorman, E Kroon, MK Carpenter, EE Baetge; 24; 11; 2006; 1392-1401; 10.1038/nbt1259; citation_id=CR2
• EMBO J; Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro; HA Russ, AV Parent, JJ Ringler, TG Hennings, GG Nair, M Shveygert, T Guo, S Puri, L Haataja, V Cirulli; 34; 13; 2015; 1759-1772; 10.15252/embj.201591058; citation_id=CR3
• Stem Cell Res; Cell aggregation optimizes the differentiation of human ESCs and iPSCs into pancreatic bud-like progenitor cells; T Toyoda, S Mae, H Tanaka, Y Kondo, M Funato, Y Hosokawa, T Sudo, Y Kawaguchi, K Osafune; 14; 2; 2015; 185-197; 10.1016/j.scr.2015.01.007; citation_id=CR4
• Nat Commun; A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells; P Saxena, BC Heng, P Bai, M Folcher, H Zulewski, M Fussenegger; 7; 2016; 11247; 10.1038/ncomms11247; citation_id=CR5

Terms in the title (10)： 転写因子 ,  mRNA ,  ヒト ,  胚幹細胞 ,  膵臓 ,  内分泌細胞 ,  分化 ,  迅速 ,  フットプリント ,  プロトコル