Art
J-GLOBAL ID：201902288659515431   Reference number：19A2817437

Integrating Drug- and Formulation-Related Properties With Gastrointestinal Tract Variability Using a Product-Specific Particle Size Approach: Case Example Ibuprofen

製品特異的粒子サイズアプローチを用いた胃腸管可変性による薬物および処方関連特性の統合:症例例イブプロフェン【JST・京大機械翻訳】
Author (6)：
Cristofoletti Rodrigo

About Cristofoletti Rodrigo

(Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, Florida 32827)

About Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, Florida 32827

, 
Hens Bart

About Hens Bart

(Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium)

About Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium

, 
Patel Nikunjkumar

About Patel Nikunjkumar

(Simcyp Limited (A Certara Company), Blades Enterprise Centre, Sheffield, UK)

About Simcyp Limited (A Certara Company), Blades Enterprise Centre, Sheffield, UK

, 
Esteban Valvanera Vozmediano

About Esteban Valvanera Vozmediano

(Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, Florida 32827)

About Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, Florida 32827

, 
Schmidt Stephan

About Schmidt Stephan

(Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, Florida 32827)

About Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, Florida 32827

, 
Dressman Jennifer

About Dressman Jennifer

(Institute of Pharmaceutical Technology, Goethe University, Frankfurt am Main, Germany)

About Institute of Pharmaceutical Technology, Goethe University, Frankfurt am Main, Germany


Material：
Journal of Pharmaceutical Sciences  (J Pharm Sci)

About Journal of Pharmaceutical Sciences


Volume： 108  Issue： 12  Page： 3842-3847  Publication year： 2019 
JST Material Number： C0260B  ISSN： 0022-3549  CODEN： JPMSAE  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)
Abstract/Point：
Abstract/Point
Japanese summary of the article(about several hundred characters).
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In the present study, an in vi...
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Thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
buffer action

About buffer action

, 
dissolution

About dissolution

, 
particle size(ratio)

About particle size(ratio)

, 
modeling

About modeling

, 
*gastrointestinal tract

About gastrointestinal tract

, 
extrapolation method

About extrapolation method

, 
carboxylic acid

About carboxylic acid

, 
aromatic compound

About aromatic compound


Semi thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
創薬

About 創薬

, 【Automatic Indexing@JST】
Author keywords (6)：
absorption

About absorption

, 
dissolution

About dissolution

, 
physiologically based pharmacokinetic (PBPK) modeling

About physiologically based pharmacokinetic (PBPK) modeling

, 
in vitro - in vivo (IVIVC) correlation(s)

About in vitro - in vivo (IVIVC) correlation(s)

, 
mechanistic modeling

About mechanistic modeling

, 
particle size

About particle size

JST classification (2)：
JST classification
Category name(code) classified by JST.
Physical pharmacy 
(GY01012A)

About Physical pharmacy

,  Physicochemical characteristics of drugs 
(GV01060M)

About Physicochemical characteristics of drugs

Substance index (1)：
Substance index
Chemical Substance indexed to the Article.
Ibuprofen

About Ibuprofen

Terms in the title (8)：
Terms in the title
Keywords automatically extracted from the title.
粒子サイズ

About 粒子サイズ

, 
胃腸管

About 胃腸管

, 
可変性

About 可変性

, 
薬物

About 薬物

, 
処方

About 処方

, 
統合

About 統合

, 
症例

About 症例

, 
イブプロフェン

About イブプロフェン


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